Risk of ESRD in prior living kidney donors
© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons..
We studied End-Stage Renal Disease (ESRD) in living kidney donors (LKDs) who donated in the United States between 1994 and 2016 (n = 123 526), using Organ Procurement and Transplantation Network and Centers for Medicare and Medicaid Services data. Two hundred eighteen LKDs developed ESRD, with a median of 11.1 years between donation and ESRD. Absolute 20-year risk was low but not uniform, with risk associated with race, age, and sex and increasing exponentially over time. LKDs had increased risk of ESRD if they were male (adjusted hazard ratio [aHR]: 1.75, 95% confidence interval [95%CI]: 1.33-2.31), had higher BMI (aHR: 1.34 per 5 kg/m2 , 95%CI: 1.10-1.64) or lower estimated GFR (aHR: 0.89 per 10 mL/min, 95% CI: 0.80-0.99), were first-degree relatives of the recipient (parent: [aHR: 2.01, 95% CI: 1.26-3.21]; full sibling [aHR: 1.87, 95%CI: 1.23-2.84]; identical twin [aHR: 19.79, 95%CI: 7.65-51.24]), or lived in lower socioeconomic status neighborhoods at donation (aHR: 0.87 per $10k increase; 95%CI: 0.77-0.99). We found a significant interaction between donation age and race, with higher risk at older ages for white LKDs (aHR: 1.26 per decade, 95%CI: 1.04-1.54), but higher risk at younger ages for black LKDs (aHR: 0.75 per decade, 95%CI: 0.57-0.99). These findings further inform risk assessment of potential LKDs.
| Errataetall: |
CommentIn: Am J Transplant. 2018 May;18(5):1041-1042. - PMID 29498805 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 18(2018), 5 vom: 26. Mai, Seite 1129-1139 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wainright, Jennifer L [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.12.2019 Date Revised 24.01.2023 published: Print-Electronic CommentIn: Am J Transplant. 2018 May;18(5):1041-1042. - PMID 29498805 Citation Status MEDLINE |
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| doi: |
10.1111/ajt.14678 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM280527926 |
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| 500 | |a CommentIn: Am J Transplant. 2018 May;18(5):1041-1042. - PMID 29498805 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 The American Society of Transplantation and the American Society of Transplant Surgeons. | ||
| 520 | |a We studied End-Stage Renal Disease (ESRD) in living kidney donors (LKDs) who donated in the United States between 1994 and 2016 (n = 123 526), using Organ Procurement and Transplantation Network and Centers for Medicare and Medicaid Services data. Two hundred eighteen LKDs developed ESRD, with a median of 11.1 years between donation and ESRD. Absolute 20-year risk was low but not uniform, with risk associated with race, age, and sex and increasing exponentially over time. LKDs had increased risk of ESRD if they were male (adjusted hazard ratio [aHR]: 1.75, 95% confidence interval [95%CI]: 1.33-2.31), had higher BMI (aHR: 1.34 per 5 kg/m2 , 95%CI: 1.10-1.64) or lower estimated GFR (aHR: 0.89 per 10 mL/min, 95% CI: 0.80-0.99), were first-degree relatives of the recipient (parent: [aHR: 2.01, 95% CI: 1.26-3.21]; full sibling [aHR: 1.87, 95%CI: 1.23-2.84]; identical twin [aHR: 19.79, 95%CI: 7.65-51.24]), or lived in lower socioeconomic status neighborhoods at donation (aHR: 0.87 per $10k increase; 95%CI: 0.77-0.99). We found a significant interaction between donation age and race, with higher risk at older ages for white LKDs (aHR: 1.26 per decade, 95%CI: 1.04-1.54), but higher risk at younger ages for black LKDs (aHR: 0.75 per decade, 95%CI: 0.57-0.99). These findings further inform risk assessment of potential LKDs | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a clinical research/practice | |
| 650 | 4 | |a donors and donation | |
| 650 | 4 | |a donors and donation: living | |
| 650 | 4 | |a ethics and public policy | |
| 650 | 4 | |a ethnicity/race | |
| 650 | 4 | |a kidney disease | |
| 650 | 4 | |a kidney transplantation/nephrology | |
| 650 | 4 | |a kidney transplantation: living donor | |
| 700 | 1 | |a Robinson, Amanda M |e verfasserin |4 aut | |
| 700 | 1 | |a Wilk, Amber R |e verfasserin |4 aut | |
| 700 | 1 | |a Klassen, David K |e verfasserin |4 aut | |
| 700 | 1 | |a Cherikh, Wida S |e verfasserin |4 aut | |
| 700 | 1 | |a Stewart, Darren E |e verfasserin |4 aut | |
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