Neuroprotective effect of morin on lead acetate- induced apoptosis by preventing cytochrome c translocation via regulation of Bax/Bcl-2 ratio
Copyright © 2018 Elsevier Inc. All rights reserved..
Lead (Pb) intoxication is a prevalent type of environmental toxicity as well as minimal amount of lead exposure is liable for neurobehavioral or perhaps intelligence defects. The present study was undertaken to investigate the beneficial effects of morin in protecting the lead acetate (PbAc)-induced oxidative stress in rat brain. PbAc intoxication resulted in motor deficit, memory impairment and oxidative stress Further, PbAc administration alters Bax/Bcl-2 expression thereby increases cytochrome c release from the mitochondria. Treatment with morin at a dose of 40 mg/kg b.wt. significantly restored back the abnormal changes that were noticed in PbAc intoxicated rats. Histopathological sections of cortex, cerebellum and hippocampus showed the extent of neuronal loss in PbAc induced rats and its restoration upon administration of morin. These outcomes imply that morin might be employed therapeutically to chelate toxic metals like Pb, thus possibly lowering PbAc-induced neurotoxicity and tissue damage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:66 |
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| Enthalten in: |
Neurotoxicology and teratology - 66(2018) vom: 06. März, Seite 35-45 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thangarajan, Sumathi [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.01.2020 Date Revised 07.01.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ntt.2018.01.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 520 | |a Copyright © 2018 Elsevier Inc. All rights reserved. | ||
| 520 | |a Lead (Pb) intoxication is a prevalent type of environmental toxicity as well as minimal amount of lead exposure is liable for neurobehavioral or perhaps intelligence defects. The present study was undertaken to investigate the beneficial effects of morin in protecting the lead acetate (PbAc)-induced oxidative stress in rat brain. PbAc intoxication resulted in motor deficit, memory impairment and oxidative stress Further, PbAc administration alters Bax/Bcl-2 expression thereby increases cytochrome c release from the mitochondria. Treatment with morin at a dose of 40 mg/kg b.wt. significantly restored back the abnormal changes that were noticed in PbAc intoxicated rats. Histopathological sections of cortex, cerebellum and hippocampus showed the extent of neuronal loss in PbAc induced rats and its restoration upon administration of morin. These outcomes imply that morin might be employed therapeutically to chelate toxic metals like Pb, thus possibly lowering PbAc-induced neurotoxicity and tissue damage | ||
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| 650 | 4 | |a Apoptosis | |
| 650 | 4 | |a Bax | |
| 650 | 4 | |a Bcl-2 | |
| 650 | 4 | |a Cognitive impairment | |
| 650 | 4 | |a Cytochrome c | |
| 650 | 4 | |a Lead acetate | |
| 650 | 4 | |a Morin | |
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| 650 | 7 | |a Neuroprotective Agents |2 NLM | |
| 650 | 7 | |a Organometallic Compounds |2 NLM | |
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| 700 | 1 | |a Somasundaram, Shanmathy |e verfasserin |4 aut | |
| 700 | 1 | |a Sakthimanogaran, Rathika |e verfasserin |4 aut | |
| 700 | 1 | |a Murugesan, Mahalakshmi |e verfasserin |4 aut | |
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