Prevalent use of combined prophylaxis of hepatitis B after liver transplantation in Italy : results of a national survey in a large cohort
BACKGROUND: Prophylaxis of hepatitis B after liver transplantation with antiviral(s) and immunoglobulins efficiently protect the majority of recipients; however recent experiences suggest a decline of HBsAg-positive candidates and the use of hepatitis B Immunoglobulin-free schedules.
METHODS: This national survey evaluated the epidemiology and clinical results of hepatitis B prophylaxis among 10,365 liver transplants performed in 25 years in 13 Italian centers.
RESULTS: With a percentage of 22, 2260 procedures were performed in HBsAg-positive recipients and 714 out of 1080 anti-HBc-positive grafts were used in HBsAg-negative recipients; a total of 2974 patients (29%) were considered at risk of hepatitis B after liver transplantation. Similar rates (18% of HBsAg-positive candidates and 15% of anti-HBc-positive grafts) were registered in the last collected year. Combined prophylaxis with Hepatitis B Immunoglobulins remained prevalent among centers and was effective in 96% of HBsAg-positive recipients and in 94% of HBsAg-negative recipients of anti-HBc-positive grafts.
CONCLUSIONS: Data from this survey confirm: the excellent results of combined prophylaxis; the past and persistent use of Hepatitis B Immunoglobulin-on and only rare -off prophylactic regimens, in contrast with the newest reports; the increasing use of anti-HBc-positive grafts; the past and present high prevalence of HBsAg-positive recipients, due to an increase in candidates with either hepatocellular carcinoma and Hepatitis Delta Virus coinfection in the last years.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Minerva gastroenterologica e dietologica - 64(2018), 1 vom: 29. März, Seite 1-9 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Marzano, Alfredo [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 27.09.2018 Date Revised 27.09.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.23736/S1121-421X.17.02407-2 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM279701659 |
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| 100 | 1 | |a Marzano, Alfredo |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prevalent use of combined prophylaxis of hepatitis B after liver transplantation in Italy |b results of a national survey in a large cohort |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 27.09.2018 | ||
| 500 | |a Date Revised 27.09.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Prophylaxis of hepatitis B after liver transplantation with antiviral(s) and immunoglobulins efficiently protect the majority of recipients; however recent experiences suggest a decline of HBsAg-positive candidates and the use of hepatitis B Immunoglobulin-free schedules | ||
| 520 | |a METHODS: This national survey evaluated the epidemiology and clinical results of hepatitis B prophylaxis among 10,365 liver transplants performed in 25 years in 13 Italian centers | ||
| 520 | |a RESULTS: With a percentage of 22, 2260 procedures were performed in HBsAg-positive recipients and 714 out of 1080 anti-HBc-positive grafts were used in HBsAg-negative recipients; a total of 2974 patients (29%) were considered at risk of hepatitis B after liver transplantation. Similar rates (18% of HBsAg-positive candidates and 15% of anti-HBc-positive grafts) were registered in the last collected year. Combined prophylaxis with Hepatitis B Immunoglobulins remained prevalent among centers and was effective in 96% of HBsAg-positive recipients and in 94% of HBsAg-negative recipients of anti-HBc-positive grafts | ||
| 520 | |a CONCLUSIONS: Data from this survey confirm: the excellent results of combined prophylaxis; the past and persistent use of Hepatitis B Immunoglobulin-on and only rare -off prophylactic regimens, in contrast with the newest reports; the increasing use of anti-HBc-positive grafts; the past and present high prevalence of HBsAg-positive recipients, due to an increase in candidates with either hepatocellular carcinoma and Hepatitis Delta Virus coinfection in the last years | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 7 | |a Hepatitis B Core Antigens |2 NLM | |
| 700 | 1 | |a Andreone, Pietro |e verfasserin |4 aut | |
| 700 | 1 | |a Boccagni, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Burra, Patrizia |e verfasserin |4 aut | |
| 700 | 1 | |a Caneschi, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Conoscitore, Pasquale F |e verfasserin |4 aut | |
| 700 | 1 | |a Coppola, Carmine |e verfasserin |4 aut | |
| 700 | 1 | |a DE Carlis, Luciano |e verfasserin |4 aut | |
| 700 | 1 | |a Fagiuoli, Stefano |e verfasserin |4 aut | |
| 700 | 1 | |a Forte, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Gaeta, Giovanni B |e verfasserin |4 aut | |
| 700 | 1 | |a Iemmolo, Rosa M |e verfasserin |4 aut | |
| 700 | 1 | |a Lotti Suffredini, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Mazzola, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Merli, Manuela |e verfasserin |4 aut | |
| 700 | 1 | |a Parrilli, Gianpaolo |e verfasserin |4 aut | |
| 700 | 1 | |a Piai, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Piras, Maria R |e verfasserin |4 aut | |
| 700 | 1 | |a Salizzoni, Mauro |e verfasserin |4 aut | |
| 700 | 1 | |a Tamè, Mariarosa |e verfasserin |4 aut | |
| 700 | 1 | |a Tisone, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Toniutto, Pierluigi |e verfasserin |4 aut | |
| 700 | 1 | |a Vennarecci, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Volpes, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Zamboni, Fausto |e verfasserin |4 aut | |
| 700 | 1 | |a Caccamo, Lucio |e verfasserin |4 aut | |
| 700 | 0 | |a ISPHeB group |e verfasserin |4 aut | |
| 700 | 1 | |a Bertuzzo, Valentina R |e investigator |4 oth | |
| 700 | 1 | |a Bongiovanni, Assunta S |e investigator |4 oth | |
| 700 | 1 | |a Brindicci, Gaetano |e investigator |4 oth | |
| 700 | 1 | |a Cocchis, Donatella |e investigator |4 oth | |
| 700 | 1 | |a Ettorre, Giuseppe M |e investigator |4 oth | |
| 700 | 1 | |a Gianni, Elena |e investigator |4 oth | |
| 700 | 1 | |a Giusto, Michela |e investigator |4 oth | |
| 700 | 1 | |a Lenisa, Ilaria |e investigator |4 oth | |
| 700 | 1 | |a Lucà, Maria G |e investigator |4 oth | |
| 700 | 1 | |a Mameli, Laura |e investigator |4 oth | |
| 700 | 1 | |a Mangoni, Iacopo |e investigator |4 oth | |
| 700 | 1 | |a Manini, Matteo A |e investigator |4 oth | |
| 700 | 1 | |a Paoli, Serena |e investigator |4 oth | |
| 700 | 1 | |a Russo, Francesco P |e investigator |4 oth | |
| 700 | 1 | |a Staiano, Laura |e investigator |4 oth | |
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