Gene editing as a promising approach for respiratory diseases
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted..
Respiratory diseases, which are leading causes of mortality and morbidity in the world, are dysfunctions of the nasopharynx, the trachea, the bronchus, the lung and the pleural cavity. Symptoms of chronic respiratory diseases, such as cough, sneezing and difficulty breathing, may seriously affect the productivity, sleep quality and physical and mental well-being of patients, and patients with acute respiratory diseases may have difficulty breathing, anoxia and even life-threatening respiratory failure. Respiratory diseases are generally heterogeneous, with multifaceted causes including smoking, ageing, air pollution, infection and gene mutations. Clinically, a single pulmonary disease can exhibit more than one phenotype or coexist with multiple organ disorders. To correct abnormal function or repair injured respiratory tissues, one of the most promising techniques is to correct mutated genes by gene editing, as some gene mutations have been clearly demonstrated to be associated with genetic or heterogeneous respiratory diseases. Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) systems are three innovative gene editing technologies developed recently. In this short review, we have summarised the structure and operating principles of the ZFNs, TALENs and CRISPR/Cas9 systems and their preclinical and clinical applications in respiratory diseases.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2018 |
---|---|
Erschienen: |
2018 |
Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
---|---|
Enthalten in: |
Journal of medical genetics - 55(2018), 3 vom: 16. März, Seite 143-149 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Bai, Yichun [VerfasserIn] |
---|
Links: |
---|
Themen: |
CRISPR/Cas9 |
---|
Anmerkungen: |
Date Completed 20.09.2019 Date Revised 20.09.2019 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1136/jmedgenet-2017-104960 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM27964938X |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM27964938X | ||
003 | DE-627 | ||
005 | 20231225023452.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2018 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1136/jmedgenet-2017-104960 |2 doi | |
028 | 5 | 2 | |a pubmed24n0932.xml |
035 | |a (DE-627)NLM27964938X | ||
035 | |a (NLM)29301855 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Bai, Yichun |e verfasserin |4 aut | |
245 | 1 | 0 | |a Gene editing as a promising approach for respiratory diseases |
264 | 1 | |c 2018 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 20.09.2019 | ||
500 | |a Date Revised 20.09.2019 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. | ||
520 | |a Respiratory diseases, which are leading causes of mortality and morbidity in the world, are dysfunctions of the nasopharynx, the trachea, the bronchus, the lung and the pleural cavity. Symptoms of chronic respiratory diseases, such as cough, sneezing and difficulty breathing, may seriously affect the productivity, sleep quality and physical and mental well-being of patients, and patients with acute respiratory diseases may have difficulty breathing, anoxia and even life-threatening respiratory failure. Respiratory diseases are generally heterogeneous, with multifaceted causes including smoking, ageing, air pollution, infection and gene mutations. Clinically, a single pulmonary disease can exhibit more than one phenotype or coexist with multiple organ disorders. To correct abnormal function or repair injured respiratory tissues, one of the most promising techniques is to correct mutated genes by gene editing, as some gene mutations have been clearly demonstrated to be associated with genetic or heterogeneous respiratory diseases. Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN) and clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) systems are three innovative gene editing technologies developed recently. In this short review, we have summarised the structure and operating principles of the ZFNs, TALENs and CRISPR/Cas9 systems and their preclinical and clinical applications in respiratory diseases | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a CRISPR/Cas9 | |
650 | 4 | |a TALEN | |
650 | 4 | |a ZFN | |
650 | 4 | |a gene editing | |
650 | 4 | |a respiratory diseases | |
650 | 7 | |a Transcription Activator-Like Effector Nucleases |2 NLM | |
650 | 7 | |a EC 3.1.- |2 NLM | |
650 | 7 | |a Zinc Finger Nucleases |2 NLM | |
650 | 7 | |a EC 3.1.- |2 NLM | |
700 | 1 | |a Liu, Yang |e verfasserin |4 aut | |
700 | 1 | |a Su, Zhenlei |e verfasserin |4 aut | |
700 | 1 | |a Ma, Yana |e verfasserin |4 aut | |
700 | 1 | |a Ren, Chonghua |e verfasserin |4 aut | |
700 | 1 | |a Zhao, Runzhen |e verfasserin |4 aut | |
700 | 1 | |a Ji, Hong-Long |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of medical genetics |d 1964 |g 55(2018), 3 vom: 16. März, Seite 143-149 |w (DE-627)NLM000228656 |x 1468-6244 |7 nnns |
773 | 1 | 8 | |g volume:55 |g year:2018 |g number:3 |g day:16 |g month:03 |g pages:143-149 |
856 | 4 | 0 | |u http://dx.doi.org/10.1136/jmedgenet-2017-104960 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 55 |j 2018 |e 3 |b 16 |c 03 |h 143-149 |