Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1
Georg Thieme Verlag KG Stuttgart · New York..
Optic nerve glioma (ONG) is associated in 10% of patients with neurofibromatosis (NF) type 1. To date no consensus has been reached regarding the therapeutic approach and prevention of visual impairment in these patients. Reports in the literature vary from a conservative approach (observation) to the use of single treatment modalities or multimodality protocols of surgical removal, radiotherapy, and/or chemotherapy. We present our experience with two siblings with ONG whose mother carries cutaneous stigmata of NF type 1. The younger sister was diagnosed 3 years after the treatment of the older sibling following recommended imaging for screening. Postoperative follow-up for 11 and 15 years, respectively, demonstrated lack of tumor regrowth and preserved vision in the contralateral eye. We discuss the treatment strategy in pediatric patients with orbital ONG associated with NF type 1.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:79 |
|---|---|
| Enthalten in: |
Journal of neurological surgery. Part A, Central European neurosurgery - 79(2018), 3 vom: 01. Mai, Seite 268-272 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Surchev, Jivko Kolev [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 28.08.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1055/s-0037-1608869 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM279577788 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM279577788 | ||
| 003 | DE-627 | ||
| 005 | 20231225023311.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1055/s-0037-1608869 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0931.xml |
| 035 | |a (DE-627)NLM279577788 | ||
| 035 | |a (NLM)29294511 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Surchev, Jivko Kolev |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Optic Nerve Glioma in Two Sisters with Family History of Neurofibromatosis Type 1 |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.08.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Georg Thieme Verlag KG Stuttgart · New York. | ||
| 520 | |a Optic nerve glioma (ONG) is associated in 10% of patients with neurofibromatosis (NF) type 1. To date no consensus has been reached regarding the therapeutic approach and prevention of visual impairment in these patients. Reports in the literature vary from a conservative approach (observation) to the use of single treatment modalities or multimodality protocols of surgical removal, radiotherapy, and/or chemotherapy. We present our experience with two siblings with ONG whose mother carries cutaneous stigmata of NF type 1. The younger sister was diagnosed 3 years after the treatment of the older sibling following recommended imaging for screening. Postoperative follow-up for 11 and 15 years, respectively, demonstrated lack of tumor regrowth and preserved vision in the contralateral eye. We discuss the treatment strategy in pediatric patients with orbital ONG associated with NF type 1 | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Nachev, Sevdalin |e verfasserin |4 aut | |
| 700 | 1 | |a Todorova, Lyudmila Pavlova |e verfasserin |4 aut | |
| 700 | 1 | |a Marinov, Marin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurological surgery. Part A, Central European neurosurgery |d 2011 |g 79(2018), 3 vom: 01. Mai, Seite 268-272 |w (DE-627)NLM197442196 |x 2193-6323 |7 nnns |
| 773 | 1 | 8 | |g volume:79 |g year:2018 |g number:3 |g day:01 |g month:05 |g pages:268-272 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1055/s-0037-1608869 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 79 |j 2018 |e 3 |b 01 |c 05 |h 268-272 | ||