Role of capsule endoscopy in alarm features and non-responsive celiac disease : A European multicenter study
© 2018 Japan Gastroenterological Endoscopy Society..
BACKGROUND AND AIM: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD.
METHODS: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed.
RESULTS: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications.
CONCLUSION: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
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| Enthalten in: |
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society - 30(2018), 4 vom: 01. Juli, Seite 461-466 |
| Sprache: |
Englisch |
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| Links: |
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| Themen: |
Capsule endoscopy |
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| Anmerkungen: |
Date Completed 20.11.2018 Date Revised 06.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/den.13002 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM279176872 |
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| 100 | 1 | |a Perez-Cuadrado-Robles, Enrique |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role of capsule endoscopy in alarm features and non-responsive celiac disease |b A European multicenter study |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 20.11.2018 | ||
| 500 | |a Date Revised 06.03.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2018 Japan Gastroenterological Endoscopy Society. | ||
| 520 | |a BACKGROUND AND AIM: The role of capsule endoscopy (CE) in established celiac disease (CD) remains unclear. Our objective was to analyze the usefulness of CE in the suspicion of complicated CD | ||
| 520 | |a METHODS: This was a retrospective multicenter study. One hundred and eighty-nine celiac patients (mean age: 46.6 ± 16.6, 30.2% males) who underwent CE for alarm symptoms (n = 86, 45.5%) or non-responsive CD (n = 103, 54.5%) were included. Diagnostic yield (DY), therapeutic impact and safety were analyzed | ||
| 520 | |a RESULTS: Capsule endoscopy was completed in 95.2% of patients (small bowel transit time: 270.5 ± 100.2 min). Global DY was 67.2%, detecting atrophic mucosa (n = 92, 48.7%), ulcerative jejunoileitis (n = 21, 11.1%), intestinal lymphoma (n = 7, 3.7%) and other enteropathies (n = 7, 3.7%, six Crohn's disease cases and one neuroendocrine tumor). The DY of CE was significantly higher in patients presenting with non-responsive disease compared to patients with alarm symptoms (73.8% vs 59.3%, P = 0.035). The new findings of the CE modified management in 59.3% of the cases. There were no major complications | ||
| 520 | |a CONCLUSION: Capsule endoscopy may be a moderately helpful and safe diagnostic tool in the suspicion of complicated CD, modifying the clinical course of these patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a capsule endoscopy | |
| 650 | 4 | |a celiac disease | |
| 650 | 4 | |a gluten | |
| 650 | 4 | |a lymphoma | |
| 650 | 4 | |a non-responsive celiac disease | |
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| 700 | 1 | |a Egea-Valenzuela, Juan |e verfasserin |4 aut | |
| 700 | 1 | |a Jimenez-Garcıa, Victoria-Alejandra |e verfasserin |4 aut | |
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