HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes : A nested case-control study
Copyright © 2017 Elsevier Inc. All rights reserved..
AIMS: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D).
METHODS: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH.
RESULTS: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17-20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI,1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004).
CONCLUSIONS: HbA1C variability is a strong predictor for HH in T1D and T2D.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Journal of diabetes and its complications - 32(2018), 2 vom: 23. Feb., Seite 203-209 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhong, Victor W [VerfasserIn] |
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| Links: |
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| Themen: |
Blood Glucose |
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| Anmerkungen: |
Date Completed 20.06.2019 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jdiacomp.2017.10.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM279065701 |
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| 100 | 1 | |a Zhong, Victor W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a HbA1C variability and hypoglycemia hospitalization in adults with type 1 and type 2 diabetes |b A nested case-control study |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Inc. All rights reserved. | ||
| 520 | |a AIMS: To determine association between HbA1C variability and hypoglycemia requiring hospitalization (HH) in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D) | ||
| 520 | |a METHODS: Using nested case-control design in electronic health record data in England, one case with first or recurrent HH was matched to one control who had not experienced HH in incident T1D and T2D adults. HbA1C variability was determined by standard deviation of ≥3 HbA1C results. Conditional logistic models were applied to determine association of HbA1C variability with first and recurrent HH | ||
| 520 | |a RESULTS: In T1D, every 1.0% increase in HbA1C variability was associated with 90% higher first HH risk (95% CI, 1.25-2.89) and 392% higher recurrent HH risk (95% CI, 1.17-20.61). In T2D, a 1.0% increase in HbA1C variability was associated with 556% higher first HH risk (95% CI, 3.88-11.08) and 573% higher recurrent HH risk (95% CI,1.59-28.51). In T2D for first HH, the association was the strongest in non-insulin non-sulfonylurea users (P<0.0001); for recurrent HH, the association was stronger in insulin users than sulfonylurea users (P=0.07). The HbA1C variability-HH association was stronger in more recent years in T2D (P≤0.004) | ||
| 520 | |a CONCLUSIONS: HbA1C variability is a strong predictor for HH in T1D and T2D | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a HbA(1C) variability | |
| 650 | 4 | |a Hospitalization | |
| 650 | 4 | |a Hypoglycemia | |
| 650 | 4 | |a Recurrent | |
| 650 | 4 | |a Type 1 diabetes | |
| 650 | 4 | |a Type 2 diabetes | |
| 650 | 7 | |a Blood Glucose |2 NLM | |
| 650 | 7 | |a Glycated Hemoglobin A |2 NLM | |
| 700 | 1 | |a Juhaeri, Juhaeri |e verfasserin |4 aut | |
| 700 | 1 | |a Cole, Stephen R |e verfasserin |4 aut | |
| 700 | 1 | |a Shay, Christina M |e verfasserin |4 aut | |
| 700 | 1 | |a Gordon-Larsen, Penny |e verfasserin |4 aut | |
| 700 | 1 | |a Kontopantelis, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Mayer-Davis, Elizabeth J |e verfasserin |4 aut | |
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