Heart rate and risk of death among patients with Pulmonary Hypertension : A 12-lead ECG analysis
Copyright © 2017 Elsevier Ltd. All rights reserved..
BACKGROUND: Despite the emergence of new therapies, Pulmonary Hypertension (PH) still has a high mortality. Several clinical, echocardiographic, biological or hemodynamic prognostic factors have been identified but are of limited predictive value for survival. We aimed to assess whether heart rate (HR) and all ECG abnormalities measured on a 12-lead ECG may help to better identify patients at high risk of death in this population.
METHODS AND RESULTS: 296 patients followed in a registry were included with all types of PH, except group 2 of the WHO clinical classification. After a median follow-up of 10 years, age, male sex, NYHA III/IV status and, among all ECG parameters, HR and corrected QT interval were associated with mortality. In multivariate analysis, HR, age and male sex remained significant independent predictors of mortality. HR has a higher predictive value in the 238 patients in sinus rhythm. In addition, only HR was significantly correlated with clinical and hemodynamic PH prognostic factors.
CONCLUSION: HR measured on a 12-lead ECG at the time of the diagnosis is a strong independent predictor of mortality in PH patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:132 |
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| Enthalten in: |
Respiratory medicine - 132(2017) vom: 24. Nov., Seite 42-49 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bouchery-Bardet, Helene [VerfasserIn] |
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| Links: |
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| Themen: |
Electrocardiogram |
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| Anmerkungen: |
Date Completed 21.08.2018 Date Revised 21.08.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.rmed.2017.09.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM278939325 |
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| 100 | 1 | |a Bouchery-Bardet, Helene |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Heart rate and risk of death among patients with Pulmonary Hypertension |b A 12-lead ECG analysis |
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| 500 | |a Date Revised 21.08.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Despite the emergence of new therapies, Pulmonary Hypertension (PH) still has a high mortality. Several clinical, echocardiographic, biological or hemodynamic prognostic factors have been identified but are of limited predictive value for survival. We aimed to assess whether heart rate (HR) and all ECG abnormalities measured on a 12-lead ECG may help to better identify patients at high risk of death in this population | ||
| 520 | |a METHODS AND RESULTS: 296 patients followed in a registry were included with all types of PH, except group 2 of the WHO clinical classification. After a median follow-up of 10 years, age, male sex, NYHA III/IV status and, among all ECG parameters, HR and corrected QT interval were associated with mortality. In multivariate analysis, HR, age and male sex remained significant independent predictors of mortality. HR has a higher predictive value in the 238 patients in sinus rhythm. In addition, only HR was significantly correlated with clinical and hemodynamic PH prognostic factors | ||
| 520 | |a CONCLUSION: HR measured on a 12-lead ECG at the time of the diagnosis is a strong independent predictor of mortality in PH patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Electrocardiogram | |
| 650 | 4 | |a Heart rate | |
| 650 | 4 | |a Pulmonary Hypertension | |
| 650 | 4 | |a QT interval | |
| 700 | 1 | |a Creveuil, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Bauer, Fabrice |e verfasserin |4 aut | |
| 700 | 1 | |a Beygui, Farzin |e verfasserin |4 aut | |
| 700 | 1 | |a Champ-Rigot, Laure |e verfasserin |4 aut | |
| 700 | 1 | |a Saloux, Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Labombarda, Fabien |e verfasserin |4 aut | |
| 700 | 1 | |a Roule, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Sabatier, Rémi |e verfasserin |4 aut | |
| 700 | 1 | |a Legallois, Damien |e verfasserin |4 aut | |
| 700 | 1 | |a Zalcman, Gérard |e verfasserin |4 aut | |
| 700 | 1 | |a Bergot, Emmanuel |e verfasserin |4 aut | |
| 700 | 1 | |a Milliez, Paul |e verfasserin |4 aut | |
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