Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality
Copyright © 2017 Elsevier Inc. All rights reserved..
The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2018 |
|---|---|
| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
|---|---|
| Enthalten in: |
Preventive medicine - 107(2018) vom: 01. Feb., Seite 81-89 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Barroso, Maria [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Body mass index |
|---|
| Anmerkungen: |
Date Completed 14.01.2019 Date Revised 17.03.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.ypmed.2017.11.013 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM278214398 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM278214398 | ||
| 003 | DE-627 | ||
| 005 | 20231225020035.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ypmed.2017.11.013 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0927.xml |
| 035 | |a (DE-627)NLM278214398 | ||
| 035 | |a (NLM)29155226 | ||
| 035 | |a (PII)S0091-7435(17)30454-1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Barroso, Maria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.01.2019 | ||
| 500 | |a Date Revised 17.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Inc. All rights reserved. | ||
| 520 | |a The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Body mass index | |
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Epidemiology | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Neoplasms | |
| 650 | 4 | |a Obesity | |
| 700 | 1 | |a Goday, Albert |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos, Rafel |e verfasserin |4 aut | |
| 700 | 1 | |a Marín-Ibañez, Alejandro |e verfasserin |4 aut | |
| 700 | 1 | |a Guembe, Maria Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Rigo, Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Tormo-Díaz, Maria José |e verfasserin |4 aut | |
| 700 | 1 | |a Moreno-Iribas, Conchi |e verfasserin |4 aut | |
| 700 | 1 | |a Cabré, Joan Josep |e verfasserin |4 aut | |
| 700 | 1 | |a Segura, Antonio |e verfasserin |4 aut | |
| 700 | 1 | |a Baena-Díez, Jose Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a de la Cámara, Agustín Gómez |e verfasserin |4 aut | |
| 700 | 1 | |a Lapetra, José |e verfasserin |4 aut | |
| 700 | 1 | |a Quesada, Miquel |e verfasserin |4 aut | |
| 700 | 1 | |a Medrano, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Berjón, Jesús |e verfasserin |4 aut | |
| 700 | 1 | |a Frontera, Guillem |e verfasserin |4 aut | |
| 700 | 1 | |a Gavrila, Diana |e verfasserin |4 aut | |
| 700 | 1 | |a Barricarte, Aurelio |e verfasserin |4 aut | |
| 700 | 1 | |a Basora, Josep |e verfasserin |4 aut | |
| 700 | 1 | |a García, José María |e verfasserin |4 aut | |
| 700 | 1 | |a García-Lareo, Manel |e verfasserin |4 aut | |
| 700 | 1 | |a Lora-Pablos, David |e verfasserin |4 aut | |
| 700 | 1 | |a Mayoral, Eduardo |e verfasserin |4 aut | |
| 700 | 1 | |a Grau, María |e verfasserin |4 aut | |
| 700 | 1 | |a Marrugat, Jaume |e verfasserin |4 aut | |
| 700 | 0 | |a FRESCO Investigators |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Preventive medicine |d 1972 |g 107(2018) vom: 01. Feb., Seite 81-89 |w (DE-627)NLM000160423 |x 1096-0260 |7 nnns |
| 773 | 1 | 8 | |g volume:107 |g year:2018 |g day:01 |g month:02 |g pages:81-89 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.ypmed.2017.11.013 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 107 |j 2018 |b 01 |c 02 |h 81-89 | ||