Y RNA derived small RNAs in Sjögren's syndrome : Candidate biomarkers?
© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd..
Anti-Ro and anti-La antibodies are important in pathogenesis and diagnosis of Sjögren's syndrome (SS). Ro60, Ro52 and La are RNA binding proteins of Y RNA, which were discovered more than three decades ago. Significance of Y RNA is not appreciated as much as Ro and La in SS. It can be hypothesised that 5'-YsRNA, short fragment derived from Y RNA may be recognized by TLR7 in pDC, which induces type I interferon signature in SS. New genomics tools, namely RNA seq, enables assay of 5'-YsRNA in blood. 5'-YsRNA has the potential to be a novel biomarker of SS.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
International journal of rheumatic diseases - 20(2017), 11 vom: 01. Nov., Seite 1763-1766 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kabeerdoss, Jayakanthan [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.08.2018 Date Revised 13.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1756-185X.13229 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM278191037 |
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| 245 | 1 | 2 | |a Y RNA derived small RNAs in Sjögren's syndrome |b Candidate biomarkers? |
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| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. | ||
| 520 | |a Anti-Ro and anti-La antibodies are important in pathogenesis and diagnosis of Sjögren's syndrome (SS). Ro60, Ro52 and La are RNA binding proteins of Y RNA, which were discovered more than three decades ago. Significance of Y RNA is not appreciated as much as Ro and La in SS. It can be hypothesised that 5'-YsRNA, short fragment derived from Y RNA may be recognized by TLR7 in pDC, which induces type I interferon signature in SS. New genomics tools, namely RNA seq, enables assay of 5'-YsRNA in blood. 5'-YsRNA has the potential to be a novel biomarker of SS | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Sjögren's syndrome | |
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| 650 | 4 | |a type I interferon | |
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| 650 | 7 | |a Genetic Markers |2 NLM | |
| 650 | 7 | |a RNA, Small Cytoplasmic |2 NLM | |
| 650 | 7 | |a Ribonucleoproteins |2 NLM | |
| 650 | 7 | |a SS-A antibodies |2 NLM | |
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| 650 | 7 | |a SS-B antibodies |2 NLM | |
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