Psychiatric morbidity and its impact on surgical outcomes for esophageal and gastric cancer patients : A nationwide cohort study
BACKGROUND: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive.
RESULTS: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality).
MATERIALS AND METHODS: Based on the Swedish National Registry for Esophageal and Gastric cancer (NREV), we constructed a nationwide prospective cohort containing 2,745 surgically treated patients in 2006-2012. Perioperative psychiatric morbidity was defined as a clinical diagnosis of psychiatric disorder, from two years before to two years after surgery. Using propensity scores, we applied inverse probability of treatment weights (IPTW)-weighted Poisson regression model to evaluate relative risk (RR) of short-term surgical outcomes in relation to perioperative psychiatric morbidity. Further, IPTW-weighted Cox proportional hazards model was used to estimate hazard ratios (HRs) for mortality that occurred after 90 days of surgery.
CONCLUSIONS: Perioperative psychiatric morbidity could worsen both short-term and long-term surgical outcomes among patients with gastric or esophageal cancer.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
Oncotarget - 8(2017), 46 vom: 06. Okt., Seite 81305-81314 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Huan [VerfasserIn] |
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| Links: |
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| Themen: |
Esophageal cancer |
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| Anmerkungen: |
Date Revised 28.07.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.18632/oncotarget.18347 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM277804213 |
|---|
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| 245 | 1 | 0 | |a Psychiatric morbidity and its impact on surgical outcomes for esophageal and gastric cancer patients |b A nationwide cohort study |
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| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a BACKGROUND: Due to the lack of detailed clinical information, existed evidence regarding a link between psychiatric factors and adverse cancer prognosis was inclusive | ||
| 520 | |a RESULTS: We identified 1,340 patients (48.8%) with perioperative psychiatric morbidity. Preoperative psychiatric morbidity was significantly associated with both general and surgical complications within 30 days (RR = 1.3, 95% confidence interval [CI] 1.1-1.5), and the risk of death within 90 days (RR = 1.6; 95% CI 1.1-2.2) after surgery. The hazards for mortality beyond 90 days was approximately 2-fold increased among patients with perioperative psychiatric morbidity (HR = 2.0, 95% CI 1.7-2.3 for overall mortality) | ||
| 520 | |a MATERIALS AND METHODS: Based on the Swedish National Registry for Esophageal and Gastric cancer (NREV), we constructed a nationwide prospective cohort containing 2,745 surgically treated patients in 2006-2012. Perioperative psychiatric morbidity was defined as a clinical diagnosis of psychiatric disorder, from two years before to two years after surgery. Using propensity scores, we applied inverse probability of treatment weights (IPTW)-weighted Poisson regression model to evaluate relative risk (RR) of short-term surgical outcomes in relation to perioperative psychiatric morbidity. Further, IPTW-weighted Cox proportional hazards model was used to estimate hazard ratios (HRs) for mortality that occurred after 90 days of surgery | ||
| 520 | |a CONCLUSIONS: Perioperative psychiatric morbidity could worsen both short-term and long-term surgical outcomes among patients with gastric or esophageal cancer | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a esophageal cancer | |
| 650 | 4 | |a gastric cancer | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a psychiatric morbidity | |
| 650 | 4 | |a surgery | |
| 700 | 1 | |a Zhu, Jianwei |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Donghao |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Fang |e verfasserin |4 aut | |
| 700 | 1 | |a Ye, Weimin |e verfasserin |4 aut | |
| 700 | 1 | |a Lundell, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Johansson, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Lindblad, Mats |e verfasserin |4 aut | |
| 700 | 1 | |a Nilsson, Magnus |e verfasserin |4 aut | |
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