Japanese Encephalitis Virus Transmitted Via Blood Transfusion, Hong Kong, China

Japanese encephalitis virus (JEV) is a mosquitoborne virus endemic to China and Southeast Asia that causes severe encephalitis in <1% of infected persons. Transmission of JEV via blood transfusion has not been reported. We report transmission of JEV via blood donation products from an asymptomatic viremic donor to 2 immunocompromised recipients. One recipient on high-dose immunosuppressive drugs received JEV-positive packed red blood cells after a double lung transplant; severe encephalitis and a poor clinical outcome resulted. JEV RNA was detected in serum, cerebrospinal fluid, and bronchoalveolar lavage fluid specimens. The second recipient had leukemia and received platelets after undergoing chemotherapy. This patient was asymptomatic; JEV infection was confirmed in this person by IgM seroconversion. This study illustrates that, consistent with other pathogenic flaviviruses, JEV can be transmitted via blood products. Targeted donor screening and pathogen reduction technologies could be used to prevent transfusion-transmitted JEV infection in highly JEV-endemic areas.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:24

Enthalten in:

Emerging infectious diseases - 24(2018), 1 vom: 03. Jan.

Sprache:

Englisch

Beteiligte Personen:

Cheng, Vincent C C [VerfasserIn]
Sridhar, Siddharth [VerfasserIn]
Wong, Shuk-Ching [VerfasserIn]
Wong, Sally C Y [VerfasserIn]
Chan, Jasper F W [VerfasserIn]
Yip, Cyril C Y [VerfasserIn]
Chau, Chi-Hung [VerfasserIn]
Au, Timmy W K [VerfasserIn]
Hwang, Yu-Yan [VerfasserIn]
Yau, Carol S W [VerfasserIn]
Lo, Janice Y C [VerfasserIn]
Lee, Cheuk-Kwong [VerfasserIn]
Yuen, Kwok-Yung [VerfasserIn]

Links:

Volltext

Themen:

Asymptomatic
Blood transfusion
Case Reports
China
Encephalitis
Immunocompromised host
Infection control
Japanese encephalitis virus
Journal Article
Packed red blood cells
Platelets
Research Support, Non-U.S. Gov't
Vector-borne infections
Viral encephalitis
Viruses

Anmerkungen:

Date Completed 03.07.2018

Date Revised 13.11.2018

published: Print-Electronic

Citation Status MEDLINE

doi:

10.3201/eid2401.171297

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM277125677