Exposure to electronic cigarette vapors affects pulmonary and systemic expression of circadian molecular clock genes
© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society..
E-cigarette use has exploded in the past years, especially among young adults and smokers desiring to quit. While concerns are mostly based on the presence of nicotine and flavors, pulmonary effects of propylene glycol and glycerol inhalation, the main solvents of e-liquid have not been thoroughly investigated. In this preclinical study, mice were exposed 2 h daily for up to 8 weeks to vapors of propylene glycol and/or glycerol generated by an e-cigarette. Lung transcriptome analysis revealed it affected the expression level of genes of the circadian molecular clock, despite causing no inflammatory response. Periodical sacrifices showed that the rhythmicity of these regulatory genes was indeed altered in the lungs, but also in the liver, kidney, skeletal muscle, and brain. E-cigarette exposure also altered the expression of rhythmic genes (i.e., hspa1a and hspa1b), suggesting that alterations to the 'clock genes' could translate into systemic biological alterations. This study reveals that the major solvents used in e-cigarettes propylene glycol and glycerol, not nicotine or flavors, have unsuspected effects on gene expression of the molecular clock that are to be taken seriously, especially considering the fundamental role of the circadian rhythm in health and disease.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
|---|---|
| Enthalten in: |
Physiological reports - 5(2017), 19 vom: 15. Okt. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lechasseur, Ariane [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 30.05.2018 Date Revised 09.01.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.14814/phy2.13440 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM277070643 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM277070643 | ||
| 003 | DE-627 | ||
| 005 | 20231225013404.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.14814/phy2.13440 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0923.xml |
| 035 | |a (DE-627)NLM277070643 | ||
| 035 | |a (NLM)29038357 | ||
| 035 | |a (PII)e13440 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lechasseur, Ariane |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Exposure to electronic cigarette vapors affects pulmonary and systemic expression of circadian molecular clock genes |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 30.05.2018 | ||
| 500 | |a Date Revised 09.01.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. | ||
| 520 | |a E-cigarette use has exploded in the past years, especially among young adults and smokers desiring to quit. While concerns are mostly based on the presence of nicotine and flavors, pulmonary effects of propylene glycol and glycerol inhalation, the main solvents of e-liquid have not been thoroughly investigated. In this preclinical study, mice were exposed 2 h daily for up to 8 weeks to vapors of propylene glycol and/or glycerol generated by an e-cigarette. Lung transcriptome analysis revealed it affected the expression level of genes of the circadian molecular clock, despite causing no inflammatory response. Periodical sacrifices showed that the rhythmicity of these regulatory genes was indeed altered in the lungs, but also in the liver, kidney, skeletal muscle, and brain. E-cigarette exposure also altered the expression of rhythmic genes (i.e., hspa1a and hspa1b), suggesting that alterations to the 'clock genes' could translate into systemic biological alterations. This study reveals that the major solvents used in e-cigarettes propylene glycol and glycerol, not nicotine or flavors, have unsuspected effects on gene expression of the molecular clock that are to be taken seriously, especially considering the fundamental role of the circadian rhythm in health and disease | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Animal model | |
| 650 | 4 | |a Glycerol | |
| 650 | 4 | |a Propylene glycol | |
| 650 | 4 | |a circadian molecular clock | |
| 650 | 4 | |a electronic cigarette | |
| 650 | 4 | |a lungs | |
| 650 | 7 | |a HSP70 Heat-Shock Proteins |2 NLM | |
| 650 | 7 | |a Hsp70.3 protein, mouse |2 NLM | |
| 650 | 7 | |a heat-shock protein 70.1 |2 NLM | |
| 650 | 7 | |a Propylene Glycol |2 NLM | |
| 650 | 7 | |a 6DC9Q167V3 |2 NLM | |
| 650 | 7 | |a Glycerol |2 NLM | |
| 650 | 7 | |a PDC6A3C0OX |2 NLM | |
| 700 | 1 | |a Jubinville, Éric |e verfasserin |4 aut | |
| 700 | 1 | |a Routhier, Joanie |e verfasserin |4 aut | |
| 700 | 1 | |a Bérubé, Jean-Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Hamel-Auger, Mélanie |e verfasserin |4 aut | |
| 700 | 1 | |a Talbot, Maude |e verfasserin |4 aut | |
| 700 | 1 | |a Lamothe, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Aubin, Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Paré, Marie-Ève |e verfasserin |4 aut | |
| 700 | 1 | |a Beaulieu, Marie-Josée |e verfasserin |4 aut | |
| 700 | 1 | |a Bossé, Yohan |e verfasserin |4 aut | |
| 700 | 1 | |a Duchaine, Caroline |e verfasserin |4 aut | |
| 700 | 1 | |a Morissette, Mathieu C |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physiological reports |d 2013 |g 5(2017), 19 vom: 15. Okt. |w (DE-627)NLM228197236 |x 2051-817X |7 nnns |
| 773 | 1 | 8 | |g volume:5 |g year:2017 |g number:19 |g day:15 |g month:10 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.14814/phy2.13440 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 5 |j 2017 |e 19 |b 15 |c 10 | ||