Pseudomonas aeruginosa infections in chronic obstructive pulmonary disease : Role of long-term antibiotic treatment
Chronic Pseudomonas aeruginosa colonization in the airways of patients with chronic obstructive pulmonary disease (COPD) is probably associated with increased mortality and morbidity and a faster progress of COPD, although this has not been conclusively proven by studies. Studies demonstrating an improvement in prognosis in COPD patients by early eradication of Pseudomonas or at least a reduction of the bacterial burden by either inhaled or oral antibiotic maintenance therapy, are missing. An impact on the exacerbation rate has only been shown for macrolide maintenance treatment; however, this effect could be explained by the inclusion of patients with bronchiectasis in the studies. This is a group of patients for whom the effect of this kind of antibiotic treatment is well known. Further studies on the prevention and treatment of chronic Pseudomonas colonization in COPD patients are urgently needed. The stability of the respiratory microbiome probably plays an essential role in the course of the disease and should be established as a study endpoint.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
|---|---|
| Enthalten in: |
Der Internist - 58(2017), 11 vom: 01. Nov., Seite 1142-1149 |
| Sprache: |
Deutsch |
|---|
| Weiterer Titel: |
Pseudomonas-aeruginosa-Infektion bei chronisch obstruktiver Lungenerkrankung : Stellenwert der Antibiotikadauertherapie |
|---|
| Beteiligte Personen: |
Rohde, G G U [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Anti-Bacterial Agents |
|---|
| Anmerkungen: |
Date Completed 08.11.2018 Date Revised 13.11.2018 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00108-017-0332-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM276530756 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM276530756 | ||
| 003 | DE-627 | ||
| 005 | 20231225012223.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2017 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1007/s00108-017-0332-y |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0921.xml |
| 035 | |a (DE-627)NLM276530756 | ||
| 035 | |a (NLM)28983645 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a ger | ||
| 100 | 1 | |a Rohde, G G U |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Pseudomonas aeruginosa infections in chronic obstructive pulmonary disease |b Role of long-term antibiotic treatment |
| 246 | 3 | 3 | |a Pseudomonas-aeruginosa-Infektion bei chronisch obstruktiver Lungenerkrankung : Stellenwert der Antibiotikadauertherapie |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.11.2018 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Chronic Pseudomonas aeruginosa colonization in the airways of patients with chronic obstructive pulmonary disease (COPD) is probably associated with increased mortality and morbidity and a faster progress of COPD, although this has not been conclusively proven by studies. Studies demonstrating an improvement in prognosis in COPD patients by early eradication of Pseudomonas or at least a reduction of the bacterial burden by either inhaled or oral antibiotic maintenance therapy, are missing. An impact on the exacerbation rate has only been shown for macrolide maintenance treatment; however, this effect could be explained by the inclusion of patients with bronchiectasis in the studies. This is a group of patients for whom the effect of this kind of antibiotic treatment is well known. Further studies on the prevention and treatment of chronic Pseudomonas colonization in COPD patients are urgently needed. The stability of the respiratory microbiome probably plays an essential role in the course of the disease and should be established as a study endpoint | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Bronchiectasis | |
| 650 | 4 | |a COPD | |
| 650 | 4 | |a Macrolides | |
| 650 | 4 | |a Pseudomonas aeruginosa | |
| 650 | 4 | |a Therapy | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Macrolides |2 NLM | |
| 700 | 1 | |a Welte, T |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Der Internist |d 1960 |g 58(2017), 11 vom: 01. Nov., Seite 1142-1149 |w (DE-627)NLM000030767 |x 1432-1289 |7 nnns |
| 773 | 1 | 8 | |g volume:58 |g year:2017 |g number:11 |g day:01 |g month:11 |g pages:1142-1149 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00108-017-0332-y |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 58 |j 2017 |e 11 |b 01 |c 11 |h 1142-1149 | ||