Autoimmune Hepatitis : Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome
Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Journal of clinical and experimental hepatology - 7(2017), 3 vom: 15. Sept., Seite 269-273 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Acharya, Gyanendra K [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Revised 30.09.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.jceh.2017.03.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM276404238 |
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| 100 | 1 | |a Acharya, Gyanendra K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Autoimmune Hepatitis |b Diagnostic Dilemma When It Is Disguised as Iron Overload Syndrome |
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| 500 | |a Date Revised 30.09.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a Elevated serum ferritin level is a common finding in iron overload syndrome, autoimmune and viral hepatitis, alcoholic and nonalcoholic fatty liver diseases. High transferrin saturation is not a common finding in above diseases except for iron overload syndrome. We encountered a challenging case of 73-year-old female who presented with yellowish discoloration of skin, dark color urine and dull abdominal pain. Initial laboratory tests reported mild anemia; elevated bilirubin, liver enzymes, and transferrin saturation. We came to the final diagnosis of autoimmune hepatitis after extensive workups. Autoimmune hepatitis is a rare disease, and the diagnosis can be further complicated by a similar presentation of iron overload syndrome. Markedly elevated transferrin saturation can simulate iron overload syndrome, but a liver biopsy can guide physicians to navigate the diagnosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a AIH, autoimmune hepatitis | |
| 650 | 4 | |a ALP, alkaline phosphatase | |
| 650 | 4 | |a ALT, alanine aminotransferase | |
| 650 | 4 | |a AMA, antimicrosomal antibody | |
| 650 | 4 | |a ANA, antinuclear antibody | |
| 650 | 4 | |a AST, aspartate aminotransferase | |
| 650 | 4 | |a Autoimmune disease | |
| 650 | 4 | |a Autoimmune hepatitis | |
| 650 | 4 | |a BUN, blood urea nitrogen | |
| 650 | 4 | |a CMV, cytomegalovirus | |
| 650 | 4 | |a CT, computed tomography | |
| 650 | 4 | |a Diagnostic dilemma | |
| 650 | 4 | |a EBV, Epstein–Barr virus | |
| 650 | 4 | |a ESR, erythrocyte sedimentation rate | |
| 650 | 4 | |a HHC, hereditary hemochromatosis | |
| 650 | 4 | |a HLA, human leukocyte antigen | |
| 650 | 4 | |a INR, international normalized ratio | |
| 650 | 4 | |a Ig, immunoglobulin | |
| 650 | 4 | |a Iron overload syndrome | |
| 650 | 4 | |a LDH, lactate dehydrogenase | |
| 650 | 4 | |a LFT, liver function test | |
| 650 | 4 | |a MRI, magnetic resonance imaging | |
| 650 | 4 | |a PT, prothrombin time | |
| 650 | 4 | |a PTT, partial thromboplastin time | |
| 650 | 4 | |a PTU, propylthiouracil | |
| 650 | 4 | |a RBC, red blood cell | |
| 650 | 4 | |a TIBC, total iron binding capacity | |
| 650 | 4 | |a Transferrin saturation | |
| 650 | 4 | |a WBC, white blood cell | |
| 650 | 4 | |a anti-LKM, anti-liver kidney microsomal | |
| 650 | 4 | |a anti-SMA, anti-smooth muscle antibody | |
| 700 | 1 | |a Liao, Hung-I |e verfasserin |4 aut | |
| 700 | 1 | |a Frunza-Stefan, Simona |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Ronakkumar |e verfasserin |4 aut | |
| 700 | 1 | |a Khaing, Moe |e verfasserin |4 aut | |
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