Breast Milk Human Cytomegalovirus (CMV) Viral Load and the Establishment of Breast Milk CMV-pp65-Specific CD8 T Cells in Human CMV Infected Mothers
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com..
The role of human cytomegalovirus (HCMV)-specific T-cell responses in breast milk of HCMV-seropositive mothers is not well defined. In these studies, we demonstrate that the frequency of cytomegalovirus (CMV)-pp65-specific T-cell responses in peripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells in both sample sources when compared with CD4+ T cells. The frequency of pp55-specific CD8 T cells producing interferon γ (IFN-γ) alone or dual IFN-γ/granzyme rB producers is increased in breast milk compared with PBMCs. Lastly, we observed a positive correlation between breast milk viral load and the CD8 pp65-specific response, suggesting that local virus replication drives antigen-specific CD8 T cells into the breast.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:216 |
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| Enthalten in: |
The Journal of infectious diseases - 216(2017), 9 vom: 27. Nov., Seite 1176-1179 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moylan, David C [VerfasserIn] |
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| Links: |
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| Themen: |
Breast milk |
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| Anmerkungen: |
Date Completed 12.12.2017 Date Revised 15.12.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jix457 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM276386310 |
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| 500 | |a Date Revised 15.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissionsoup.com. | ||
| 520 | |a The role of human cytomegalovirus (HCMV)-specific T-cell responses in breast milk of HCMV-seropositive mothers is not well defined. In these studies, we demonstrate that the frequency of cytomegalovirus (CMV)-pp65-specific T-cell responses in peripheral blood mononuclear cells (PBMCs) and breast milk cells (BMCs) is increased for CD8+ T cells in both sample sources when compared with CD4+ T cells. The frequency of pp55-specific CD8 T cells producing interferon γ (IFN-γ) alone or dual IFN-γ/granzyme rB producers is increased in breast milk compared with PBMCs. Lastly, we observed a positive correlation between breast milk viral load and the CD8 pp65-specific response, suggesting that local virus replication drives antigen-specific CD8 T cells into the breast | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a CD8 T cells | |
| 650 | 4 | |a breast milk | |
| 650 | 4 | |a cell-mediated immunity | |
| 650 | 4 | |a human cytomegalovirus (HCMV) | |
| 650 | 4 | |a mucosal immunity | |
| 700 | 1 | |a Pati, Sunil K |e verfasserin |4 aut | |
| 700 | 1 | |a Ross, Shannon A |e verfasserin |4 aut | |
| 700 | 1 | |a Fowler, Karen B |e verfasserin |4 aut | |
| 700 | 1 | |a Boppana, Suresh B |e verfasserin |4 aut | |
| 700 | 1 | |a Sabbaj, Steffanie |e verfasserin |4 aut | |
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