Circulating steroid hormone variations throughout different stages of prostate cancer

© 2017 Society for Endocrinology..

Steroid hormones play a central role in the maintenance and progression of prostate cancer. The androgen receptor is the primary driver of tumor cell proliferation and is activated by the androgens testosterone and 5α-dihydrotestosterone. Inhibition of this pathway through medical or surgical castration improves survival in the majority of advanced prostate cancer patients. However, conversion of adrenal androgen precursors and alternative steroidogenic pathways have been found to contribute to tumor progression and resistance to treatment. The emergence of highly accurate detection methods allows us to study steroidogenic mechanisms in more detail, even after treatment with potent steroidogenic inhibitors such as the CYP17A1 inhibitor abiraterone. A clear overview of steroid hormone levels in patients throughout the local, metastatic and castration-resistant stages of prostate cancer and treatment modalities is key toward a better understanding of their role in tumor progression and treatment resistance. In this review, we summarize the currently available data on steroid hormones that have been implicated in the various stages of prostate cancer. Additionally, this review addresses the implications of these findings, highlights important studies in this field and identifies current gaps in literature.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:24

Enthalten in:

Endocrine-related cancer - 24(2017), 11 vom: 06. Nov., Seite R403-R420

Sprache:

Englisch

Beteiligte Personen:

Snaterse, Gido [VerfasserIn]
Visser, Jenny A [VerfasserIn]
Arlt, Wiebke [VerfasserIn]
Hofland, Johannes [VerfasserIn]

Links:

Volltext

Themen:

Androgens
Circulating markers
Hormones
Journal Article
Prostate cancer
Research Support, Non-U.S. Gov't
Review
Steroids

Anmerkungen:

Date Completed 07.06.2018

Date Revised 09.08.2018

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1530/ERC-17-0155

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM275946657