Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system : preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics
Due to the absence of lactone form of hydroxycamptothecin, the commercially available hydroxycamptothecin injection exhibits inefficient therapeutic effects. In this study, we constructed a novel delivery system (thermosensitive magnetic liposomes) that protects lactone form of hydroxycamptothecin from blood or water. After hydroxycamptothecin was loaded into the thermosensitive magnetic liposome (HCPT/TML), its in vitro and in vivo antitumor activity and microdialysis-based tumour pharmacokinetics were determined. The results demonstrated that HCPT/TMLs possessed favourable physicochemical features and significant cytotoxicity against the Huh-7 cells in vitro. In the in vivo antitumor study and tumour pharmacokinetics, HCPT/TMLs displayed effective targeting delivery and antitumor effects, which corresponded to the determined hydroxycamptothecin concentration in tumour tissue. In conclusion, this thermal and magnetic dual-responsive system can efficiently deliver hydroxycamptothecin to tumour tissue and has great potential application in cancer treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Journal of drug targeting - 26(2018), 4 vom: 10. Apr., Seite 345-356 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Hai-Mei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 16.07.2019 Date Revised 16.07.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/1061186X.2017.1380654 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM275911438 |
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| 100 | 1 | |a Zhu, Hai-Mei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Hydroxycamptothecin liposomes based on thermal and magnetic dual-responsive system |b preparation, in vitro and in vivo antitumor activity, microdialysis-based tumor pharmacokinetics |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.07.2019 | ||
| 500 | |a Date Revised 16.07.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Due to the absence of lactone form of hydroxycamptothecin, the commercially available hydroxycamptothecin injection exhibits inefficient therapeutic effects. In this study, we constructed a novel delivery system (thermosensitive magnetic liposomes) that protects lactone form of hydroxycamptothecin from blood or water. After hydroxycamptothecin was loaded into the thermosensitive magnetic liposome (HCPT/TML), its in vitro and in vivo antitumor activity and microdialysis-based tumour pharmacokinetics were determined. The results demonstrated that HCPT/TMLs possessed favourable physicochemical features and significant cytotoxicity against the Huh-7 cells in vitro. In the in vivo antitumor study and tumour pharmacokinetics, HCPT/TMLs displayed effective targeting delivery and antitumor effects, which corresponded to the determined hydroxycamptothecin concentration in tumour tissue. In conclusion, this thermal and magnetic dual-responsive system can efficiently deliver hydroxycamptothecin to tumour tissue and has great potential application in cancer treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Hydroxycamptothecin | |
| 650 | 4 | |a antitumor activity | |
| 650 | 4 | |a liposomes | |
| 650 | 4 | |a microdialysis | |
| 650 | 4 | |a pharmacokinetics | |
| 650 | 4 | |a targeting delivery | |
| 650 | 4 | |a thermosensitive release | |
| 650 | 7 | |a Antineoplastic Agents, Phytogenic |2 NLM | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Liposomes |2 NLM | |
| 650 | 7 | |a hydroxycamptothecinum |2 NLM | |
| 650 | 7 | |a Camptothecin |2 NLM | |
| 650 | 7 | |a XT3Z54Z28A |2 NLM | |
| 700 | 1 | |a Gu, Jin-Hui |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Xie, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Ling, Jia-Jun |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:26 |g year:2018 |g number:4 |g day:10 |g month:04 |g pages:345-356 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/1061186X.2017.1380654 |3 Volltext |
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