Review on Synthetic Chemistry and Antibacterial Importance of Thiazole Derivatives

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BACKGROUND: Thiazole is one of the leading heterocyclic five-member ring compounds that contain nitrogen and sulphur atom. Many natural and/or synthetic compounds contain thiazole as an essential moiety and possess diverse therapeutic activities. The thiazole ring was modified at different positions to generate new molecules with potent antibacterial activities. Thus, the present review enumerates the antibacterial importance of thiazole and its derivatives.

METHOD: The mining of literature has been performed using different database which includes only peer-reviewed journals. The quality of retrieved papers was appraised using standard tools. Moreover, the significant papers were described in detail to focus on thiazole derivatives showing considerable antibacterial activity.

RESULT: The present review describes the chemistry, SAR (Structure Activity Relationship) studies and antibacterial importance of thiazole with different synthetic procedures.

CONCLUSION: This particular study certainly benefits the researchers interested in exploiting the antibacterial activity of thiazoles in search of novel agents.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:15

Enthalten in:

Current drug discovery technologies - 15(2018), 3 vom: 01., Seite 214-228

Sprache:

Englisch

Beteiligte Personen:

Kashyap, Ankita [VerfasserIn]
Adhikari, Nayana [VerfasserIn]
Das, Arpita [VerfasserIn]
Shakya, Anshul [VerfasserIn]
Ghosh, Surajit Kumar [VerfasserIn]
Singh, Udaya Pratap [VerfasserIn]
Bhat, Hans Raj [VerfasserIn]

Links:

Volltext

Themen:

Anti-Bacterial Agents
Antibacterial activity
Chemistry
DNA gyrase
Derivatives
Journal Article
Review
Synthesis.
Thiazole
Thiazoles

Anmerkungen:

Date Completed 01.08.2019

Date Revised 01.08.2019

published: Print

Citation Status MEDLINE

doi:

10.2174/1570163814666170911144036

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM275721124