The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension : a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial)
OBJECTIVES: To investigate, whether renal denervation (RDN) improves arterial stiffness, central blood pressure (C-BP) and heart rate variability (HRV) in patients with treatment resistant hypertension.
METHODS: ReSET was a randomized, sham-controlled, double-blinded trial (NCT01459900). RDN was performed by a single experienced operator using the Medtronic unipolar Symplicity FlexTM catheter. C-BP, carotid-femoral pulse wave velocity (PWV), and HRV were obtained at baseline and after six months with the SphygmoCor®-device.
RESULTS: Fifty-three patients (77% of the ReSET-cohort) were included in this substudy. The groups were similar at baseline (SHAM/RDN): n = 27/n = 26; 78/65% males; age 59 ± 9/54 ± 8 years (mean ± SD); systolic brachial BP 158 ± 18/154 ± 17 mmHg; systolic 24-hour ambulatory BP 153 ± 14/151 ± 13 mmHg. Changes in PWV (0.1 ± 1.9 (SHAM) vs. -0.6 ± 1.3 (RDN) m/s), systolic C-BP (-2 ± 17 (SHAM) vs. -8 ± 16 (RDN) mmHg), diastolic C-BP (-2 ± 9 (SHAM) vs. -5 ± 9 (RDN) mmHg), and augmentation index (0.7 ± 7.0 (SHAM) vs. 1.0 ± 7.4 (RDN) %) were not significantly different after six months. Changes in HRV-parameters were also not significantly different. Baseline HRV or PWV did not predict BP-response after RDN.
CONCLUSIONS: In a sham-controlled setting, there were no significant effects of RDN on arterial stiffness, C-BP and HRV. Thus, the idea of BP-independent effects of RDN on large arteries and cardiac autonomic activity is not supported.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Blood pressure - 26(2017), 6 vom: 22. Dez., Seite 366-380 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peters, Christian Daugaard [VerfasserIn] |
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| Links: |
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| Themen: |
Arterial stiffness |
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| Anmerkungen: |
Date Completed 29.06.2018 Date Revised 08.04.2022 published: Print-Electronic ClinicalTrials.gov: NCT01459900 Citation Status MEDLINE |
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| doi: |
10.1080/08037051.2017.1368368 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM275032280 |
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| 100 | 1 | |a Peters, Christian Daugaard |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effect of renal denervation on arterial stiffness, central blood pressure and heart rate variability in treatment resistant essential hypertension |b a substudy of a randomized sham-controlled double-blinded trial (the ReSET trial) |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 29.06.2018 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT01459900 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To investigate, whether renal denervation (RDN) improves arterial stiffness, central blood pressure (C-BP) and heart rate variability (HRV) in patients with treatment resistant hypertension | ||
| 520 | |a METHODS: ReSET was a randomized, sham-controlled, double-blinded trial (NCT01459900). RDN was performed by a single experienced operator using the Medtronic unipolar Symplicity FlexTM catheter. C-BP, carotid-femoral pulse wave velocity (PWV), and HRV were obtained at baseline and after six months with the SphygmoCor®-device | ||
| 520 | |a RESULTS: Fifty-three patients (77% of the ReSET-cohort) were included in this substudy. The groups were similar at baseline (SHAM/RDN): n = 27/n = 26; 78/65% males; age 59 ± 9/54 ± 8 years (mean ± SD); systolic brachial BP 158 ± 18/154 ± 17 mmHg; systolic 24-hour ambulatory BP 153 ± 14/151 ± 13 mmHg. Changes in PWV (0.1 ± 1.9 (SHAM) vs. -0.6 ± 1.3 (RDN) m/s), systolic C-BP (-2 ± 17 (SHAM) vs. -8 ± 16 (RDN) mmHg), diastolic C-BP (-2 ± 9 (SHAM) vs. -5 ± 9 (RDN) mmHg), and augmentation index (0.7 ± 7.0 (SHAM) vs. 1.0 ± 7.4 (RDN) %) were not significantly different after six months. Changes in HRV-parameters were also not significantly different. Baseline HRV or PWV did not predict BP-response after RDN | ||
| 520 | |a CONCLUSIONS: In a sham-controlled setting, there were no significant effects of RDN on arterial stiffness, C-BP and HRV. Thus, the idea of BP-independent effects of RDN on large arteries and cardiac autonomic activity is not supported | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a heart rate variability | |
| 650 | 4 | |a pulse wave velocity | |
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| 700 | 1 | |a Vase, Henrik |e verfasserin |4 aut | |
| 700 | 1 | |a Bech Nørgaard, Jesper |e verfasserin |4 aut | |
| 700 | 1 | |a Christensen, Kent Lodberg |e verfasserin |4 aut | |
| 700 | 1 | |a Schroeder, Anne Pauline |e verfasserin |4 aut | |
| 700 | 1 | |a Rickers, Hans Joachim von Hofe |e verfasserin |4 aut | |
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