Radical Redox-Relay Catalysis : Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes
We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses radical intermediates for selective C-N bond cleavage and formation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:139 |
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| Enthalten in: |
Journal of the American Chemical Society - 139(2017), 35 vom: 06. Sept., Seite 12141-12144 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hao, Wei [VerfasserIn] |
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| Links: |
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| Themen: |
Alkenes |
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| Anmerkungen: |
Date Completed 14.06.2018 Date Revised 14.06.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1021/jacs.7b06723 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274988836 |
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| 100 | 1 | |a Hao, Wei |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Radical Redox-Relay Catalysis |b Formal [3+2] Cycloaddition of N-Acylaziridines and Alkenes |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 14.06.2018 | ||
| 500 | |a Date Revised 14.06.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a We report Ti-catalyzed radical formal [3+2] cycloadditions of N-acylaziridines and alkenes. This method provides an efficient approach to the synthesis of pyrrolidines, structural units prevalent in bioactive compounds and organocatalysts, from readily available starting materials. The overall redox-neutral reaction was achieved via a redox-relay mechanism, which harnesses radical intermediates for selective C-N bond cleavage and formation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 7 | |a Alkenes |2 NLM | |
| 650 | 7 | |a Aziridines |2 NLM | |
| 650 | 7 | |a Titanium |2 NLM | |
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| 700 | 1 | |a Wu, Xiangyu |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, James Z |e verfasserin |4 aut | |
| 700 | 1 | |a Siu, Juno C |e verfasserin |4 aut | |
| 700 | 1 | |a MacMillan, Samantha N |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Song |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of the American Chemical Society |d 1945 |g 139(2017), 35 vom: 06. Sept., Seite 12141-12144 |w (DE-627)NLM00000569X |x 1520-5126 |7 nnns |
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