Serum calcitonin reference values for calcium stimulation tests by electrochemiluminescence immunoassay in Japanese men with non-medullary thyroid carcinoma
PURPOSE: Calcitonin is the most sensitive tumor marker of medullary thyroid carcinoma (MTC) and a calcium stimulation test is used to improve this sensitivity. In Japan, the electrochemiluminescence immunoassay (ECLIA) is currently the only test performed to measure serum calcitonin. There is a gender difference in the reference value of serum calcitonin; however, a reference upper limit for use with ECLIA has been reported only for women, but not for men.
METHODS: We conducted the calcium stimulation test using ECLIA in 21 men with non-medullary thyroid carcinoma (non-MTC), before and after total thyroidectomy.
RESULTS: Preoperatively, the basal calcitonin values were within normal limits in all patients. They increased to a mean value of 37.6 pg/mL after calcium stimulation, and we calculated that the reference upper limit was 83.7 pg/mL. The stimulation test results after total thyroidectomy showed undetectable basal and stimulated calcitonin values in every patient (<0.5 pg/mL).
CONCLUSIONS: To our knowledge, this is the first study to calculate reference values for this stimulation test using an ECLIA in men with non-MTC. We propose that men can be regarded as biochemically cured or as having normal serum calcitonin values when the stimulated calcitonin values obtained by ECLIA are <83.7 pg/mL before and <0.5 pg/mL after total thyroidectomy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:48 |
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| Enthalten in: |
Surgery today - 48(2018), 2 vom: 18. Feb., Seite 223-228 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kihara, Minoru [VerfasserIn] |
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| Links: |
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| Themen: |
9007-12-9 |
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| Anmerkungen: |
Date Completed 28.02.2018 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00595-017-1578-7 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274950626 |
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| 100 | 1 | |a Kihara, Minoru |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum calcitonin reference values for calcium stimulation tests by electrochemiluminescence immunoassay in Japanese men with non-medullary thyroid carcinoma |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 28.02.2018 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: Calcitonin is the most sensitive tumor marker of medullary thyroid carcinoma (MTC) and a calcium stimulation test is used to improve this sensitivity. In Japan, the electrochemiluminescence immunoassay (ECLIA) is currently the only test performed to measure serum calcitonin. There is a gender difference in the reference value of serum calcitonin; however, a reference upper limit for use with ECLIA has been reported only for women, but not for men | ||
| 520 | |a METHODS: We conducted the calcium stimulation test using ECLIA in 21 men with non-medullary thyroid carcinoma (non-MTC), before and after total thyroidectomy | ||
| 520 | |a RESULTS: Preoperatively, the basal calcitonin values were within normal limits in all patients. They increased to a mean value of 37.6 pg/mL after calcium stimulation, and we calculated that the reference upper limit was 83.7 pg/mL. The stimulation test results after total thyroidectomy showed undetectable basal and stimulated calcitonin values in every patient (<0.5 pg/mL) | ||
| 520 | |a CONCLUSIONS: To our knowledge, this is the first study to calculate reference values for this stimulation test using an ECLIA in men with non-MTC. We propose that men can be regarded as biochemically cured or as having normal serum calcitonin values when the stimulated calcitonin values obtained by ECLIA are <83.7 pg/mL before and <0.5 pg/mL after total thyroidectomy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Calcitonin | |
| 650 | 4 | |a Calcium stimulation | |
| 650 | 4 | |a Electrochemiluminescence immunoassay (ECLIA) | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Medullary thyroid carcinoma | |
| 650 | 7 | |a Biomarkers, Tumor |2 NLM | |
| 650 | 7 | |a Calcitonin |2 NLM | |
| 650 | 7 | |a 9007-12-9 |2 NLM | |
| 650 | 7 | |a Calcium |2 NLM | |
| 650 | 7 | |a SY7Q814VUP |2 NLM | |
| 700 | 1 | |a Miyauchi, Akira |e verfasserin |4 aut | |
| 700 | 1 | |a Kudo, Takumi |e verfasserin |4 aut | |
| 700 | 1 | |a Hirokawa, Mitsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Miya, Akihiro |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:48 |g year:2018 |g number:2 |g day:18 |g month:02 |g pages:223-228 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00595-017-1578-7 |3 Volltext |
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