Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma
© 2017 Wiley Periodicals, Inc..
BACKGROUND AND OBJECTIVES: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI.
METHODS: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome.
RESULTS: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047).
CONCLUSION: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
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| Enthalten in: |
Journal of surgical oncology - 117(2018), 2 vom: 01. Feb., Seite 236-244 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Matsuo, Koji [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 06.03.2018 Date Revised 01.10.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jso.24801 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274612038 |
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| 100 | 1 | |a Matsuo, Koji |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 06.03.2018 | ||
| 500 | |a Date Revised 01.10.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 Wiley Periodicals, Inc. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI | ||
| 520 | |a METHODS: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome | ||
| 520 | |a RESULTS: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047) | ||
| 520 | |a CONCLUSION: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a low-grade serous | |
| 650 | 4 | |a lymphovascular space invasion | |
| 650 | 4 | |a ovarian cancer | |
| 700 | 1 | |a Wong, Kwong-Kwok |e verfasserin |4 aut | |
| 700 | 1 | |a Fotopoulou, Christina |e verfasserin |4 aut | |
| 700 | 1 | |a Blake, Erin A |e verfasserin |4 aut | |
| 700 | 1 | |a Robertson, Sharon E |e verfasserin |4 aut | |
| 700 | 1 | |a Pejovic, Tanja |e verfasserin |4 aut | |
| 700 | 1 | |a Frimer, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Pardeshi, Vishakha |e verfasserin |4 aut | |
| 700 | 1 | |a Hu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Choi, Jong-Sun |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Charlotte C |e verfasserin |4 aut | |
| 700 | 1 | |a Richmond, Abby M |e verfasserin |4 aut | |
| 700 | 1 | |a Marcus, Jenna Z |e verfasserin |4 aut | |
| 700 | 1 | |a Hilliard, Maren A M |e verfasserin |4 aut | |
| 700 | 1 | |a Mostofizadeh, Sayedamin |e verfasserin |4 aut | |
| 700 | 1 | |a Mhawech-Fauceglia, Paulette |e verfasserin |4 aut | |
| 700 | 1 | |a Abdulfatah, Eman |e verfasserin |4 aut | |
| 700 | 1 | |a Post, Miriam D |e verfasserin |4 aut | |
| 700 | 1 | |a Saglam, Ozlen |e verfasserin |4 aut | |
| 700 | 1 | |a Shahzad, Mian M K |e verfasserin |4 aut | |
| 700 | 1 | |a Karabakhtsian, Rouzan G |e verfasserin |4 aut | |
| 700 | 1 | |a Ali-Fehmi, Rouba |e verfasserin |4 aut | |
| 700 | 1 | |a Gabra, Hani |e verfasserin |4 aut | |
| 700 | 1 | |a Roman, Lynda D |e verfasserin |4 aut | |
| 700 | 1 | |a Sood, Anil K |e verfasserin |4 aut | |
| 700 | 1 | |a Gershenson, David M |e verfasserin |4 aut | |
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