An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone
Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocyte-colony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:56 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 56(2017), 16 vom: 15. Aug., Seite 2199-2203 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Koh, Shiro [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 29.01.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.8268-16 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274551160 |
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| 100 | 1 | |a Koh, Shiro |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An Elderly Woman with Anti-neutrophil Antibody-positive Agranulocytosis Who Responded to High-dose Intravenous Methylprednisolone |
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| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Although anti-neutrophil antibodies (ANAs) often exist and immunoreaction may be involved in agranulocytosis, few reports have so far described ANA-positive cases of agranulocytosis with an unknown etiology. We herein describe the case of a 69-year-old woman who presented with ANA-positive agranulocytosis. In this case, both the withdrawal of the drugs that had possibly caused neutropenia and the use of granulocyte-colony stimulating factor (G-CSF) were ineffective treatment measures. Approximately 2 weeks after the discontinuation of the suspected drugs, we initiated corticosteroid pulse therapy; the neutrophil count recovered by day 19 of steroid therapy. High-dose methylprednisolone therapy should thus be considered for patients demonstrating ANA-positive agranulocytosis with an unknown etiology that is refractory to G-CSF treatment | ||
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| 700 | 1 | |a Kubo, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Kuroda, Maiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nishimoto, Mitsutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshimura, Takuro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakashima, Yasuhiro |e verfasserin |4 aut | |
| 700 | 1 | |a Nakane, Takahiko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamae, Hirohisa |e verfasserin |4 aut | |
| 700 | 1 | |a Ohsawa, Masahiko |e verfasserin |4 aut | |
| 700 | 1 | |a Hino, Masayuki |e verfasserin |4 aut | |
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