Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians : A multicenter, randomized, parallel-group, delayed-start design study
Copyright © 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved..
BACKGROUND: Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL).
METHODS: We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT.
RESULTS: The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction.
CONCLUSIONS: rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Allergology international : official journal of the Japanese Society of Allergology - 67(2018), 2 vom: 15. Apr., Seite 209-216 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Itoh-Nagato, Naoka [VerfasserIn] |
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| Links: |
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| Themen: |
Clinical Trial |
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| Anmerkungen: |
Date Completed 17.09.2018 Date Revised 17.09.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.alit.2017.07.007 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274523248 |
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| 100 | 1 | |a Itoh-Nagato, Naoka |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Desensitization to a whole egg by rush oral immunotherapy improves the quality of life of guardians |b A multicenter, randomized, parallel-group, delayed-start design study |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Revised 17.09.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Patients with food allergies and their families have a significantly reduced health-related quality of life (QOL) | ||
| 520 | |a METHODS: We performed a multicenter, randomized, parallel-group, delayed-start design study to clarify the efficacy and safety of rush oral immunotherapy (rOIT) and its impact on the participants' daily life and their guardians (UMIN000003943). Forty-five participants were randomly divided into an early-start group and a late-start group. The early-start group received rOIT for 3 months, while the late-start group continued the egg elimination diet (control). In the next stage, both groups received OIT until all participants had finished 12 months of maintenance OIT | ||
| 520 | |a RESULTS: The ratio of the participants in whom an increase of the TD was achieved in the first stage was significantly higher in the early-start group (87.0%), than in the late-start group (22.7%). The QOL of the guardians in the early-start group significantly improved after the first stage (65.2%), in comparison to the late-start group (31.8%). During 12 months of rOIT, the serum ovomucoid-specific IgE levels, the percentage of CD203c+ basophils upon stimulation with egg white, and the wheal size to egg white were decreased, while the serum ovomucoid-specific IgG4 levels were increased. However, approximately 80% of the participants in the early-start group showed an allergic reaction during the first stage of the study, whereas none of the patients in the late-start group experienced an allergic reaction | ||
| 520 | |a CONCLUSIONS: rOIT induced desensitization to egg and thus improved the QOL of guardians; however, the participants experienced frequent allergic reactions due to the treatment | ||
| 650 | 4 | |a Clinical Trial | |
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| 650 | 4 | |a Multicenter Study | |
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| 650 | 4 | |a Guardians | |
| 650 | 4 | |a Oral immunotherapy | |
| 650 | 4 | |a Quality of life | |
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| 700 | 1 | |a Nagao, Mizuho |e verfasserin |4 aut | |
| 700 | 1 | |a Fujisawa, Takao |e verfasserin |4 aut | |
| 700 | 1 | |a Shimojo, Naoki |e verfasserin |4 aut | |
| 700 | 1 | |a Iwata, Tsutomu |e verfasserin |4 aut | |
| 700 | 0 | |a J-OIT group |e verfasserin |4 aut | |
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| 700 | 1 | |a Arakawa, Koichi |e investigator |4 oth | |
| 700 | 1 | |a Arima, Takayasu |e investigator |4 oth | |
| 700 | 1 | |a Fukushima, Keitaro |e investigator |4 oth | |
| 700 | 1 | |a Hoshioka, Akira |e investigator |4 oth | |
| 700 | 1 | |a Igarashi, Takashi |e investigator |4 oth | |
| 700 | 1 | |a Itazawa, Toshiko |e investigator |4 oth | |
| 700 | 1 | |a Itoh, Komei |e investigator |4 oth | |
| 700 | 1 | |a Kameda, Makoto |e investigator |4 oth | |
| 700 | 1 | |a Kando, Naoyuki |e investigator |4 oth | |
| 700 | 1 | |a Kato, Izumi |e investigator |4 oth | |
| 700 | 1 | |a Kitabayashi, Taeru |e investigator |4 oth | |
| 700 | 1 | |a Kobayashi, Takae |e investigator |4 oth | |
| 700 | 1 | |a Koyama, Harumi |e investigator |4 oth | |
| 700 | 1 | |a Morita, Yoshinori |e investigator |4 oth | |
| 700 | 1 | |a Nakano, Taiji |e investigator |4 oth | |
| 700 | 1 | |a Suzuki, Shuichi |e investigator |4 oth | |
| 700 | 1 | |a Takaoka, Yuri |e investigator |4 oth | |
| 700 | 1 | |a Tomiita, Minako |e investigator |4 oth | |
| 700 | 1 | |a Yagi, Hisako |e investigator |4 oth | |
| 700 | 1 | |a Yajima, Yuko |e investigator |4 oth | |
| 700 | 1 | |a Yamaide, Akiko |e investigator |4 oth | |
| 700 | 1 | |a Yasui, Masahiro |e investigator |4 oth | |
| 700 | 1 | |a Yoshihara, Shigemi |e investigator |4 oth | |
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