Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.org..
BACKGROUND: Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity.
OBJECTIVES: The present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet.
METHODS: Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated.
RESULTS: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors.
CONCLUSION: This study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Protein and peptide letters - 24(2017), 9 vom: 17. Nov., Seite 861-868 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Crespo, Thaisa Soares [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 21.08.2018 Date Revised 21.08.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/0929866524666170728155926 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM274329352 |
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| 100 | 1 | |a Crespo, Thaisa Soares |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effects of Sleeve Gastrectomy on the Metabolic Profile and on the Expression of Renin-Angiotensin System in Adipose Tissue of Obese Rats |
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| 500 | |a Date Revised 21.08.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.org. | ||
| 520 | |a BACKGROUND: Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of obesity | ||
| 520 | |a OBJECTIVES: The present study aimed to assess the effects of SG on the metabolic and inflammatory profile and renin-angiotensin system (RAS) expression in the white adipose tissue of male rats with obesity induced by a high-fat diet | ||
| 520 | |a METHODS: Male Wistar rats were treated with a standard diet or high-fat diet and submitted to SG or sham surgery. The glycemic and lipid profiles and gene expression of inflammatory markers and RAS components in adipose tissue were evaluated | ||
| 520 | |a RESULTS: SG led to weight loss, decreased adiposity (p < 0.01) and a reduction in plasma glucose (p < 0.05), C-peptide (p < 0.05), insulin (p < 0.001) and total cholesterol (p < 0.05) levels. In addition, SG led to a decrease in the expression of tumor necrosis factor-alpha (TNF-α) (p < 0.01), interleukin- 6 (IL-6) (p < 0.001), angiotensinogen (AGT) (p < 0.001) and angiotensin converting enzyme (ACE) (p < 0.05) and increased the expression of angiotensin converting enzyme 2 (ACE2) (p < 0.05) in white adipose tissue. No statistically significant differences were observed for AT1 (p = 0.10) and Mas (p = 0.22) receptors | ||
| 520 | |a CONCLUSION: This study showed that SG leads to weight loss and improves metabolic parameters. Changes in the expression of RAS components and of inflammatory molecules in adipose tissue seem to play a role the before beneficial effects of the SG | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Obesity | |
| 650 | 4 | |a bariatric surgery | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a renin-angiotensin system | |
| 650 | 4 | |a sleeve gastrectomy. | |
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| 700 | 1 | |a Andrade, Joao Marcus Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Paraiso, Alanna Fernandes |e verfasserin |4 aut | |
| 700 | 1 | |a de Farias Lelis, Deborah |e verfasserin |4 aut | |
| 700 | 1 | |a Chagas, Pablo Vinicyus Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Jorge, Antonio Sergio Barcala |e verfasserin |4 aut | |
| 700 | 1 | |a Ferreira, Wagner Leite |e verfasserin |4 aut | |
| 700 | 1 | |a de Paula, Alfredo Mauricio Batista |e verfasserin |4 aut | |
| 700 | 1 | |a Guimaraes, Andre Luiz Sena |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Sergio Henrique Sousa |e verfasserin |4 aut | |
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