Number of recent stressful life events and incident cardiovascular disease : Moderation by lifetime depressive disorder
Copyright © 2017 Elsevier Inc. All rights reserved..
OBJECTIVE: We investigated whether number of recent stressful life events is associated with incident cardiovascular disease (CVD) and whether this relationship is stronger in adults with a history of clinical depression.
METHODS: Prospective data from 28,583 U.S. adults (mean age=45years) initially free of CVD who participated in Waves 1 (2001-2002) and 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Number of past-year stressful life events (Wave 1), lifetime depressive disorder (Wave 1), and incident CVD (Wave 2) were determined by structured interviews.
RESULTS: There were 1069 cases of incident CVD. Each additional stressful life event was associated with a 15% increased odds of incident CVD [Odds Ratio (OR)=1.15, 95% Confidence Interval (CI): 1.11, 1.19]. As hypothesized, a stressful life events by lifetime depressive disorder interaction was detected (P=0.003). Stratified analyses indicated that stressful life events had a stronger association with incident CVD among adults with (OR=1.18, 95% CI: 1.10, 1.27, n=4908) versus without (OR=1.10, 95% CI: 1.07, 1.14, n=23,675) a lifetime depressive disorder.
CONCLUSION: Our findings suggest that a greater number of recent stressful life events elevate the risk of new-onset CVD and that this risk is potentiated in adults with a history of clinical depression.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:99 |
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| Enthalten in: |
Journal of psychosomatic research - 99(2017) vom: 17. Aug., Seite 149-154 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Berntson, Jessica [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular diseases |
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| Anmerkungen: |
Date Completed 17.01.2018 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jpsychores.2017.06.008 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM273881108 |
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| 100 | 1 | |a Berntson, Jessica |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Number of recent stressful life events and incident cardiovascular disease |b Moderation by lifetime depressive disorder |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 17.01.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: We investigated whether number of recent stressful life events is associated with incident cardiovascular disease (CVD) and whether this relationship is stronger in adults with a history of clinical depression | ||
| 520 | |a METHODS: Prospective data from 28,583 U.S. adults (mean age=45years) initially free of CVD who participated in Waves 1 (2001-2002) and 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Number of past-year stressful life events (Wave 1), lifetime depressive disorder (Wave 1), and incident CVD (Wave 2) were determined by structured interviews | ||
| 520 | |a RESULTS: There were 1069 cases of incident CVD. Each additional stressful life event was associated with a 15% increased odds of incident CVD [Odds Ratio (OR)=1.15, 95% Confidence Interval (CI): 1.11, 1.19]. As hypothesized, a stressful life events by lifetime depressive disorder interaction was detected (P=0.003). Stratified analyses indicated that stressful life events had a stronger association with incident CVD among adults with (OR=1.18, 95% CI: 1.10, 1.27, n=4908) versus without (OR=1.10, 95% CI: 1.07, 1.14, n=23,675) a lifetime depressive disorder | ||
| 520 | |a CONCLUSION: Our findings suggest that a greater number of recent stressful life events elevate the risk of new-onset CVD and that this risk is potentiated in adults with a history of clinical depression | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cardiovascular diseases | |
| 650 | 4 | |a Depressive disorder | |
| 650 | 4 | |a Epidemiologic studies | |
| 650 | 4 | |a Life change events | |
| 650 | 4 | |a Prospective studies | |
| 650 | 4 | |a Stress, psychological | |
| 700 | 1 | |a Patel, Jay S |e verfasserin |4 aut | |
| 700 | 1 | |a Stewart, Jesse C |e verfasserin |4 aut | |
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