Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction : access to functionalized 1,2,3-triazoles
The Ugi multicomponent reaction has been used as an important synthetic route to obtain compounds with potential biological activity. We present the rapid and efficient synthesis of [Formula: see text]-amino-1,3-dicarbonyl compounds in moderate to good yields via Ugi flow chemistry reactions performed with a continuous flow reactor. Such [Formula: see text]-amino-1,3-dicarbonyl compounds can act as precursors for the production of [Formula: see text]-amino acids via hydrolysis of the ethyl ester group as well as building blocks for the synthesis of novel compounds with the 1,2,3-triazole ring. The [Formula: see text]-amino acid derivatives of the Ugi flow chemistry reaction products were then used for dipeptide synthesis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
Molecular diversity - 21(2017), 4 vom: 16. Nov., Seite 893-902 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vasconcelos, Stanley N S [VerfasserIn] |
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| Links: |
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| Themen: |
Aldehydes |
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| Anmerkungen: |
Date Completed 20.07.2018 Date Revised 06.03.2020 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s11030-017-9764-5 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM273788132 |
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| 245 | 1 | 0 | |a Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction |b access to functionalized 1,2,3-triazoles |
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| 500 | |a Date Revised 06.03.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The Ugi multicomponent reaction has been used as an important synthetic route to obtain compounds with potential biological activity. We present the rapid and efficient synthesis of [Formula: see text]-amino-1,3-dicarbonyl compounds in moderate to good yields via Ugi flow chemistry reactions performed with a continuous flow reactor. Such [Formula: see text]-amino-1,3-dicarbonyl compounds can act as precursors for the production of [Formula: see text]-amino acids via hydrolysis of the ethyl ester group as well as building blocks for the synthesis of novel compounds with the 1,2,3-triazole ring. The [Formula: see text]-amino acid derivatives of the Ugi flow chemistry reaction products were then used for dipeptide synthesis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Click chemistry | |
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| 650 | 7 | |a Triazoles |2 NLM | |
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| 700 | 1 | |a Caracelli, Ignez |e verfasserin |4 aut | |
| 700 | 1 | |a Stefani, Hélio A |e verfasserin |4 aut | |
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