In vitro antiplasmodial and cytotoxic activities of sesquiterpene lactones from Vernonia fimbrillifera Less. (Asteraceae)
Due to the in vitro antiplasmodial activity of leaf extracts from Vernonia fimbrillifera Less. (Asteraceae), a bioactivity-guided fractionation was carried out. Three sesquiterpene lactones were isolated, namely 8-(4'-hydroxymethacrylate)-dehydromelitensin (1), onopordopicrin (2) and 8α-[4'-hydroxymethacryloyloxy]-4-epi-sonchucarpolide (3). Their structures were elucidated by spectroscopic methods (1D and 2D NMR and MS analyses) and by comparison with published data. The isolated compounds exhibited antiplasmodial activity with IC50 values ≤ 5 μg/mL. Cytotoxicity of the compounds against a human cancer cell line (HeLa) and a mouse lung epithelial cell line (MLE12) was assessed to determine selectivity. Compound 3 displayed promising selective antiplasmodial activity (SI > 10).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
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| Enthalten in: |
Natural product research - 32(2018), 12 vom: 10. Juni, Seite 1463-1466 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bordignon, Annélise [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.06.2018 Date Revised 04.06.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14786419.2017.1350665 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM273696459 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Due to the in vitro antiplasmodial activity of leaf extracts from Vernonia fimbrillifera Less. (Asteraceae), a bioactivity-guided fractionation was carried out. Three sesquiterpene lactones were isolated, namely 8-(4'-hydroxymethacrylate)-dehydromelitensin (1), onopordopicrin (2) and 8α-[4'-hydroxymethacryloyloxy]-4-epi-sonchucarpolide (3). Their structures were elucidated by spectroscopic methods (1D and 2D NMR and MS analyses) and by comparison with published data. The isolated compounds exhibited antiplasmodial activity with IC50 values ≤ 5 μg/mL. Cytotoxicity of the compounds against a human cancer cell line (HeLa) and a mouse lung epithelial cell line (MLE12) was assessed to determine selectivity. Compound 3 displayed promising selective antiplasmodial activity (SI > 10) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antiplasmodial activity | |
| 650 | 4 | |a Asteraceae | |
| 650 | 4 | |a Reunion Island | |
| 650 | 4 | |a Vernonia fimbrillifera Less | |
| 650 | 4 | |a sesquiterpene lactones | |
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| 650 | 7 | |a Lactones |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
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| 700 | 1 | |a Ledoux, Allison |e verfasserin |4 aut | |
| 700 | 1 | |a Campos, Pierre-Eric |e verfasserin |4 aut | |
| 700 | 1 | |a Clerc, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Hermann, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Quetin-Leclercq, Joëlle |e verfasserin |4 aut | |
| 700 | 1 | |a Cieckiewicz, Ewa |e verfasserin |4 aut | |
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