Anemia and growth retardation associated with Schistosoma haematobium infection in Mali : a possible subtle impact of a neglected tropical disease
© The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
Background: The aim of this cross-sectional study was to investigate a possible association of Schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of Mali.
Methods: Urine, feces and blood samples from 399 participants of both sexes (2-40 years of age) were analyzed and supplemented by anthropometric measurements.
Results: S. haematobium prevalence was 79.8%, S. mansoni 13.2% and Plasmodium falciparum 80.2%. S. haematobium infection intensity as five categories was significantly associated with anemia; i.e., odds of having anemia in the highest and the next highest category was 3.25 (95% CL 1.61-6.55; p<0.01) and 2.45 (95% CL 1.28-4.70; p<0.01), respectively, of that in the three lower categories combined after adjusting for age group and gender and the interaction between the two factors. Anemia was most pronounced in the 2-5 year olds males (55.5%, n=98). P. falciparum infection was not significantly associated with anemia. Stunting (body mass index [BMI] for age z-score<-2.00) was observed in 2.6% (2/78) of the 2-5 years olds and in 7.7% (14/182) in the 6-19 years age group. Lower BMI-z-scores (as continuous variable) were associated with anemia (p<0.05) while high intensity of S. haematobium infection was not significant when adjusting for age group and anemia. Participants with malaria infection had lower z-scores (as continuous variables) of weight and height for age. Lower height for age z-scores were also associated with anemia.
Conclusions: S. haematobium infection is likely to impact on child growth and possibly also anemia in all age groups and advocates for inclusion of whole populations into future control programes.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
|---|---|
| Enthalten in: |
Transactions of the Royal Society of Tropical Medicine and Hygiene - 111(2017), 4 vom: 01. Apr., Seite 144-153 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Stecher, Chalotte W [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
6490C9U457 |
|---|
| Anmerkungen: |
Date Completed 11.04.2018 Date Revised 08.04.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/trstmh/trx037 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM273498592 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM273498592 | ||
| 003 | DE-627 | ||
| 005 | 20231225001351.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/trstmh/trx037 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0911.xml |
| 035 | |a (DE-627)NLM273498592 | ||
| 035 | |a (NLM)28673023 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Stecher, Chalotte W |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Anemia and growth retardation associated with Schistosoma haematobium infection in Mali |b a possible subtle impact of a neglected tropical disease |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 11.04.2018 | ||
| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author 2017. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
| 520 | |a Background: The aim of this cross-sectional study was to investigate a possible association of Schistosoma haematobium with child growth development and describe a plausible schistosomiasis-related anemia in children and adults in a highly schistosomiasis endemic area of Mali | ||
| 520 | |a Methods: Urine, feces and blood samples from 399 participants of both sexes (2-40 years of age) were analyzed and supplemented by anthropometric measurements | ||
| 520 | |a Results: S. haematobium prevalence was 79.8%, S. mansoni 13.2% and Plasmodium falciparum 80.2%. S. haematobium infection intensity as five categories was significantly associated with anemia; i.e., odds of having anemia in the highest and the next highest category was 3.25 (95% CL 1.61-6.55; p<0.01) and 2.45 (95% CL 1.28-4.70; p<0.01), respectively, of that in the three lower categories combined after adjusting for age group and gender and the interaction between the two factors. Anemia was most pronounced in the 2-5 year olds males (55.5%, n=98). P. falciparum infection was not significantly associated with anemia. Stunting (body mass index [BMI] for age z-score<-2.00) was observed in 2.6% (2/78) of the 2-5 years olds and in 7.7% (14/182) in the 6-19 years age group. Lower BMI-z-scores (as continuous variable) were associated with anemia (p<0.05) while high intensity of S. haematobium infection was not significant when adjusting for age group and anemia. Participants with malaria infection had lower z-scores (as continuous variables) of weight and height for age. Lower height for age z-scores were also associated with anemia | ||
| 520 | |a Conclusions: S. haematobium infection is likely to impact on child growth and possibly also anemia in all age groups and advocates for inclusion of whole populations into future control programes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anemia | |
| 650 | 4 | |a Growth | |
| 650 | 4 | |a Morbidity | |
| 650 | 4 | |a NTD | |
| 650 | 4 | |a Schistosomiasis | |
| 650 | 4 | |a Sub-Saharan Africa | |
| 650 | 7 | |a Anthelmintics |2 NLM | |
| 650 | 7 | |a Praziquantel |2 NLM | |
| 650 | 7 | |a 6490C9U457 |2 NLM | |
| 650 | 7 | |a Albendazole |2 NLM | |
| 650 | 7 | |a F4216019LN |2 NLM | |
| 700 | 1 | |a Sacko, Moussa |e verfasserin |4 aut | |
| 700 | 1 | |a Madsen, Henry |e verfasserin |4 aut | |
| 700 | 1 | |a Wilson, Shona |e verfasserin |4 aut | |
| 700 | 1 | |a Wejse, Christian |e verfasserin |4 aut | |
| 700 | 1 | |a Keita, Adama D |e verfasserin |4 aut | |
| 700 | 1 | |a Landouré, Aly |e verfasserin |4 aut | |
| 700 | 1 | |a Traoré, Mamadou S |e verfasserin |4 aut | |
| 700 | 1 | |a Kallestrup, Per |e verfasserin |4 aut | |
| 700 | 1 | |a Petersen, Eskild |e verfasserin |4 aut | |
| 700 | 1 | |a Vennervald, Birgitte |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transactions of the Royal Society of Tropical Medicine and Hygiene |d 1945 |g 111(2017), 4 vom: 01. Apr., Seite 144-153 |w (DE-627)NLM000035653 |x 1878-3503 |7 nnns |
| 773 | 1 | 8 | |g volume:111 |g year:2017 |g number:4 |g day:01 |g month:04 |g pages:144-153 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/trstmh/trx037 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 111 |j 2017 |e 4 |b 01 |c 04 |h 144-153 | ||