Antidiabetic Drugs in Alzheimer's Disease : Mechanisms of Action and Future Perspectives
Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2017 |
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| Enthalten in: |
Journal of diabetes research - 2017(2017) vom: 26., Seite 7420796 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Femminella, Grazia Daniela [VerfasserIn] |
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| Links: |
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| Themen: |
Hypoglycemic Agents |
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| Anmerkungen: |
Date Completed 11.04.2018 Date Revised 29.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1155/2017/7420796 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM273336452 |
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| 520 | |a Diabetes mellitus (DM) and Alzheimer's disease (AD) are two highly prevalent conditions in the elderly population and major public health burden. In the past decades, a pathophysiological link between DM and AD has emerged and central nervous system insulin resistance might play a significant role as a common mechanism; however, other factors such as inflammation and oxidative stress seem to contribute to the shared pathophysiological link. Both preclinical and clinical studies have evaluated the possible neuroprotective mechanisms of different classes of antidiabetic medications in AD, with some promising results. Here, we review the evidence on the mechanisms of action of antidiabetic drugs and their potential use in AD | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
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| 700 | 1 | |a Bencivenga, Leonardo |e verfasserin |4 aut | |
| 700 | 1 | |a Petraglia, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Visaggi, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Gioia, Lucia |e verfasserin |4 aut | |
| 700 | 1 | |a Grieco, Fabrizio Vincenzo |e verfasserin |4 aut | |
| 700 | 1 | |a de Lucia, Claudio |e verfasserin |4 aut | |
| 700 | 1 | |a Komici, Klara |e verfasserin |4 aut | |
| 700 | 1 | |a Corbi, Graziamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Edison, Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Rengo, Giuseppe |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Nicola |e verfasserin |4 aut | |
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