Diagnosis and assessment of renal fibrosis : the state of the art
Chronic kidney disease (CKD) is defined as an alteration of kidney function and/or structure lasting for more than 3 months and is a major public health issue. Histologically, the severity of CKD correlates with the magnitude of kidney cortical interstitial fibrosis. Estimation of kidney fibrosis is crucial to assess prognosis and guide therapy in both native and allograft kidneys. Biopsy is currently the gold standard for assessing fibrosis with histological techniques. Although this procedure has become safer over recent years, complications and limitations remain. Given these restrictions, new, noninvasive techniques are necessary for the evaluation and follow-up of CKD patients. Radiological methods such as ultrasound and magnetic resonance imaging are emerging for assessment kidney fibrosis. These two techniques have advantages but also limitations. In addition to radiological assessment of fibrosis, urinary and plasma biomarkers are being developed and tested as predictive tools for histological lesions in the kidney. This article reviews the current evidence for these novel techniques in the evaluation of kidney interstitial fibrosis.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2017 |
|---|---|
| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:147 |
|---|---|
| Enthalten in: |
Swiss medical weekly - 147(2017) vom: 29., Seite w14442 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Berchtold, Lena [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 14.05.2018 Date Revised 30.07.2018 published: Electronic-eCollection Citation Status MEDLINE |
|---|
| doi: |
10.4414/smw.2017.14442 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM273131362 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM273131362 | ||
| 003 | DE-627 | ||
| 005 | 20231225000447.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4414/smw.2017.14442 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0910.xml |
| 035 | |a (DE-627)NLM273131362 | ||
| 035 | |a (NLM)28634969 | ||
| 035 | |a (PII)Swiss Med Wkly. 2017;147:w14442 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Berchtold, Lena |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Diagnosis and assessment of renal fibrosis |b the state of the art |
| 264 | 1 | |c 2017 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.05.2018 | ||
| 500 | |a Date Revised 30.07.2018 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Chronic kidney disease (CKD) is defined as an alteration of kidney function and/or structure lasting for more than 3 months and is a major public health issue. Histologically, the severity of CKD correlates with the magnitude of kidney cortical interstitial fibrosis. Estimation of kidney fibrosis is crucial to assess prognosis and guide therapy in both native and allograft kidneys. Biopsy is currently the gold standard for assessing fibrosis with histological techniques. Although this procedure has become safer over recent years, complications and limitations remain. Given these restrictions, new, noninvasive techniques are necessary for the evaluation and follow-up of CKD patients. Radiological methods such as ultrasound and magnetic resonance imaging are emerging for assessment kidney fibrosis. These two techniques have advantages but also limitations. In addition to radiological assessment of fibrosis, urinary and plasma biomarkers are being developed and tested as predictive tools for histological lesions in the kidney. This article reviews the current evidence for these novel techniques in the evaluation of kidney interstitial fibrosis | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Friedli, Iris |e verfasserin |4 aut | |
| 700 | 1 | |a Vallée, Jean-Paul |e verfasserin |4 aut | |
| 700 | 1 | |a Moll, Solange |e verfasserin |4 aut | |
| 700 | 1 | |a Martin, Pierre-Yves |e verfasserin |4 aut | |
| 700 | 1 | |a de Seigneux, Sophie |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Swiss medical weekly |d 2001 |g 147(2017) vom: 29., Seite w14442 |w (DE-627)NLM111171121 |x 1424-3997 |7 nnns |
| 773 | 1 | 8 | |g volume:147 |g year:2017 |g day:29 |g pages:w14442 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4414/smw.2017.14442 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 147 |j 2017 |b 29 |h w14442 | ||