Reproducibility discrepancies following reanalysis of raw data for a previously published study on diisononyl phthalate (DINP) in rats
A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" [1] reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011) [1], we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016) [2]. The output of our reanalysis and the discordances with the data as published in Boberg et al. (2011) [1] are highlighted herein. Further discussion of the basis for the replication discordances and the insufficiency of the Boberg et al. (2011) [1] response to address them can be found in a companion letter of correspondence (doi: 10.1016/j.reprotox.2017.03.013.; (Morfeld et al., 2011) [3]).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
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| Enthalten in: |
Data in brief - 13(2017) vom: 01. Aug., Seite 208-213 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chen, Min [VerfasserIn] |
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| Links: |
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| Themen: |
Diisononyl phthalate (DINP) |
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| Anmerkungen: |
Date Revised 26.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.dib.2017.05.043 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272950882 |
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| 520 | |a A 2011 publication by Boberg et al. entitled "Reproductive and behavioral effects of diisononyl phthalate (DINP) in perinatally exposed rats" [1] reported statistically significant changes in sperm parameters, testicular histopathology, anogenital distance and retained nipples in developing males. Using the statistical methods as reported by Boberg et al. (2011) [1], we reanalyzed the publically available raw data ([dataset] US EPA (United States Environmental Protection Agency), 2016) [2]. The output of our reanalysis and the discordances with the data as published in Boberg et al. (2011) [1] are highlighted herein. Further discussion of the basis for the replication discordances and the insufficiency of the Boberg et al. (2011) [1] response to address them can be found in a companion letter of correspondence (doi: 10.1016/j.reprotox.2017.03.013.; (Morfeld et al., 2011) [3]) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Diisononyl phthalate (DINP) | |
| 650 | 4 | |a Reproducibility | |
| 650 | 4 | |a Reproductive toxicology | |
| 650 | 4 | |a Statistical reanalysis | |
| 700 | 1 | |a Alyea, Rebecca |e verfasserin |4 aut | |
| 700 | 1 | |a Morfeld, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Otter, Rainer |e verfasserin |4 aut | |
| 700 | 1 | |a Kemmerling, Jessica |e verfasserin |4 aut | |
| 700 | 1 | |a Palermo, Christine |e verfasserin |4 aut | |
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