Midterm eGFR and Adverse Pregnancy Outcomes : The Clinical Significance of Gestational Hyperfiltration
Copyright © 2017 by the American Society of Nephrology..
BACKGROUND AND OBJECTIVES: Although hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration (MRH) on pregnancy outcomes is unknown.
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was an observational cohort study. Women with a singleton pregnancy and a serum creatinine measurement during their second trimester were followed at two university hospitals in Korea between 2001 and 2015. Those with substantial renal function impairment or who delivered during the second trimester were not considered. MRH was represented by the highest eGFR, which was calculated using the Chronic Kidney Disease Epidemiology Collaboration method. An adverse pregnancy event was defined by the composition of preterm birth (gestational age <37 weeks), low birth weight (<2.5 kg), and preeclampsia.
RESULTS: Data from 1931 pregnancies were included. The relationship between midterm eGFR and adverse pregnancy outcomes, which occurred in 538 mothers, was defined by a nonlinear U-shaped curve. The adjusted odds ratio and associated 95% confidence interval (95% CI) of an adverse pregnancy outcome for eGFR levels below and above the reference level of 120-150 ml/min per 1.73 m2 were 1.97 (95% CI, 1.34 to 2.89; P<0.001) for ≥150 ml/min per 1.73 m2; 1.57 (95% CI, 1.23 to 2.00; P<0.001) for 90-120 ml/min per 1.73 m2; and 4.93 (95% CI, 1.97 to 12.31; P<0.001) for 60-90 ml/min per 1.73 m2. Moreover, among mothers without baseline CKD, women with adverse pregnancy outcomes had less prominent MRH than those without (P<0.001).
CONCLUSIONS: We identified a unique U-shaped relationship between midterm eGFR and adverse pregnancy outcomes, and the optimal range of midterm eGFR levels was 120-150 ml/min per 1.73 m2. In those without evident functional renal impairment, the absence of prominent MRH might be a significant risk factor for poor pregnancy outcomes.
| Errataetall: |
CommentIn: Clin J Am Soc Nephrol. 2017 Jul 7;12 (7):1029-1031. - PMID 28611077 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Clinical journal of the American Society of Nephrology : CJASN - 12(2017), 7 vom: 07. Juli, Seite 1048-1056 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Park, Sehoon [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 24.04.2018 Date Revised 13.08.2023 published: Print-Electronic CommentIn: Clin J Am Soc Nephrol. 2017 Jul 7;12 (7):1029-1031. - PMID 28611077 Citation Status MEDLINE |
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| doi: |
10.2215/CJN.12101116 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272902349 |
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| 100 | 1 | |a Park, Sehoon |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Midterm eGFR and Adverse Pregnancy Outcomes |b The Clinical Significance of Gestational Hyperfiltration |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Revised 13.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Clin J Am Soc Nephrol. 2017 Jul 7;12 (7):1029-1031. - PMID 28611077 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 by the American Society of Nephrology. | ||
| 520 | |a BACKGROUND AND OBJECTIVES: Although hemodynamic adaptation plays a crucial role in maintaining gestation, the clinical significance of midterm renal hyperfiltration (MRH) on pregnancy outcomes is unknown | ||
| 520 | |a DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This was an observational cohort study. Women with a singleton pregnancy and a serum creatinine measurement during their second trimester were followed at two university hospitals in Korea between 2001 and 2015. Those with substantial renal function impairment or who delivered during the second trimester were not considered. MRH was represented by the highest eGFR, which was calculated using the Chronic Kidney Disease Epidemiology Collaboration method. An adverse pregnancy event was defined by the composition of preterm birth (gestational age <37 weeks), low birth weight (<2.5 kg), and preeclampsia | ||
| 520 | |a RESULTS: Data from 1931 pregnancies were included. The relationship between midterm eGFR and adverse pregnancy outcomes, which occurred in 538 mothers, was defined by a nonlinear U-shaped curve. The adjusted odds ratio and associated 95% confidence interval (95% CI) of an adverse pregnancy outcome for eGFR levels below and above the reference level of 120-150 ml/min per 1.73 m2 were 1.97 (95% CI, 1.34 to 2.89; P<0.001) for ≥150 ml/min per 1.73 m2; 1.57 (95% CI, 1.23 to 2.00; P<0.001) for 90-120 ml/min per 1.73 m2; and 4.93 (95% CI, 1.97 to 12.31; P<0.001) for 60-90 ml/min per 1.73 m2. Moreover, among mothers without baseline CKD, women with adverse pregnancy outcomes had less prominent MRH than those without (P<0.001) | ||
| 520 | |a CONCLUSIONS: We identified a unique U-shaped relationship between midterm eGFR and adverse pregnancy outcomes, and the optimal range of midterm eGFR levels was 120-150 ml/min per 1.73 m2. In those without evident functional renal impairment, the absence of prominent MRH might be a significant risk factor for poor pregnancy outcomes | ||
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| 700 | 1 | |a Park, Joong Shin |e verfasserin |4 aut | |
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| 700 | 1 | |a Chin, Ho Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Na, Ki Young |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Dong Ki |e verfasserin |4 aut | |
| 700 | 1 | |a Oh, Kook-Hwan |e verfasserin |4 aut | |
| 700 | 1 | |a Joo, Kwon Wook |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Yon Su |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Hajeong |e verfasserin |4 aut | |
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