P50 suppression deficits and psychopathology in Han Chinese patients with schizophrenia
Copyright © 2017 Elsevier B.V. All rights reserved..
OBJECTIVE: Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia.
METHODS: We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS).
RESULTS: Patients with schizophrenia had a significantly higher P50 gating ratio (p<0.001), longer S1 latency (p<0.05), lower S1 amplitude (p<0.01), and lower P50 difference (p<0.001) than did controls. No significant correlations were found between the P50 gating measures and the PANSS total score or subscale scores in patients with schizophrenia.
CONCLUSIONS: These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:653 |
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| Enthalten in: |
Neuroscience letters - 653(2017) vom: 13. Juli, Seite 346-350 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhu, Xiao Lin [VerfasserIn] |
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| Links: |
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| Themen: |
Age |
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| Anmerkungen: |
Date Completed 27.04.2018 Date Revised 17.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2017.06.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272860646 |
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| 100 | 1 | |a Zhu, Xiao Lin |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a P50 suppression deficits and psychopathology in Han Chinese patients with schizophrenia |
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| 500 | |a Date Completed 27.04.2018 | ||
| 500 | |a Date Revised 17.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: Numerous studies have reported P50 gating deficits in schizophrenia, though with mixed results. Moreover, few studies have explored the association between P50 gating deficits and psychopathology in Chinese patients with schizophrenia. In the present study, we investigated the P50 auditory sensory gating patterns and their correlations with clinical symptoms in a large sample of Han Chinese patients with schizophrenia | ||
| 520 | |a METHODS: We assessed P50 sensory gating with a 64-channel electroencephalography system in 133 patients with schizophrenia and 148 healthy controls. The schizophrenia symptomatology was assessed with the Positive and Negative Syndrome Scale (PANSS) | ||
| 520 | |a RESULTS: Patients with schizophrenia had a significantly higher P50 gating ratio (p<0.001), longer S1 latency (p<0.05), lower S1 amplitude (p<0.01), and lower P50 difference (p<0.001) than did controls. No significant correlations were found between the P50 gating measures and the PANSS total score or subscale scores in patients with schizophrenia | ||
| 520 | |a CONCLUSIONS: These findings suggest that the P50 sensory gating deficits identified in Chinese patients with schizophrenia may not be involved in the psychopathology of the illness | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age | |
| 650 | 4 | |a Auditory evoked potential | |
| 650 | 4 | |a P50 | |
| 650 | 4 | |a Schizophrenia | |
| 650 | 4 | |a Sensory gating | |
| 700 | 1 | |a Tan, Shu Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhi Ren |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jin Guo |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Feng Mei |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Yan Li |e verfasserin |4 aut | |
| 700 | 1 | |a Zou, Yi Zhuang |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Yun Long |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Fu De |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiang Yang |e verfasserin |4 aut | |
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