Impact of tumor size on the outcome of patients with small renal cell carcinoma
BACKGROUND: This study aims to establish potential correlation between tumor size and outcomes in patients with T1a kidney cancer registered within the surveillance, epidemiology and end results (SEER) database.
METHODS: SEER database (2004-2013) has been accessed through SEER*Stat program to determine the correlation between tumor size and cancer-specific survival in patients with T1a kidney cancer. Survival analysis was conducted through Kaplan-Meier analysis and log-rank testing.
RESULTS: Five year kidney cancer-specific survival rates show progressive decline with increasing tumor size. Moreover, kidney cancer-specific survival has been compared according to the initial local treatment modality (observation, ablation, partial or radical nephrectomy) across different size categories (<1 cm, 1-2 cm, 2-3 cm and 3-4 cm). Survival curves of different treatment modalities were almost overlapping for patients with renal mass < 1cm. For patients with tumor size 1-2 cm, treatment modalities were overlapping at the first 60 months then the curve of observation diverged (P <0.0001). For patients with tumor size 2-3 cm and 3-4 cm, the curve of observation diverged early in the time course (P <0.0001).
CONCLUSION: Primary tumor size is an important factor that should be taken into consideration when evaluating the different treatment options for patients with small kidney cancers..
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Expert review of anticancer therapy - 17(2017), 8 vom: 05. Aug., Seite 769-773 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Abdel-Rahman, Omar [VerfasserIn] |
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| Links: |
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| Themen: |
Ablation |
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| Anmerkungen: |
Date Completed 31.07.2017 Date Revised 22.12.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/14737140.2017.1340838 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272734624 |
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| 500 | |a Date Revised 22.12.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: This study aims to establish potential correlation between tumor size and outcomes in patients with T1a kidney cancer registered within the surveillance, epidemiology and end results (SEER) database | ||
| 520 | |a METHODS: SEER database (2004-2013) has been accessed through SEER*Stat program to determine the correlation between tumor size and cancer-specific survival in patients with T1a kidney cancer. Survival analysis was conducted through Kaplan-Meier analysis and log-rank testing | ||
| 520 | |a RESULTS: Five year kidney cancer-specific survival rates show progressive decline with increasing tumor size. Moreover, kidney cancer-specific survival has been compared according to the initial local treatment modality (observation, ablation, partial or radical nephrectomy) across different size categories (<1 cm, 1-2 cm, 2-3 cm and 3-4 cm). Survival curves of different treatment modalities were almost overlapping for patients with renal mass < 1cm. For patients with tumor size 1-2 cm, treatment modalities were overlapping at the first 60 months then the curve of observation diverged (P <0.0001). For patients with tumor size 2-3 cm and 3-4 cm, the curve of observation diverged early in the time course (P <0.0001) | ||
| 520 | |a CONCLUSION: Primary tumor size is an important factor that should be taken into consideration when evaluating the different treatment options for patients with small kidney cancers. | ||
| 650 | 4 | |a Comparative Study | |
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