Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus : a multicenter cross-sectional study
© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd..
AIM: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE).
METHOD: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups.
RESULTS: Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile.
CONCLUSION: Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:21 |
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| Enthalten in: |
International journal of rheumatic diseases - 21(2018), 11 vom: 10. Nov., Seite 2028-2035 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Manzano-Gamero, Victoria [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.04.2019 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/1756-185X.13117 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272733636 |
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| 041 | |a eng | ||
| 100 | 1 | |a Manzano-Gamero, Victoria |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of ethnicity on clinical presentation and risk of antiphospholipid syndrome in Roma and Caucasian patients with systemic lupus erythematosus |b a multicenter cross-sectional study |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 09.04.2019 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd. | ||
| 520 | |a AIM: To determine if there are ethnic differences in the prevalence of antiphospholipid syndrome (APS), clinical presentation and autoantibody profile between Roma and Caucasian patients with systemic lupus erythematosus (SLE) | ||
| 520 | |a METHOD: A cross-sectional study was conducted including data from Roma and Caucasian SLE patients consecutively attending six hospitals in Spain. Socio-demographic characteristics, prevalence of APS, clinical and analytical features of SLE and APS were compared between ethnic groups | ||
| 520 | |a RESULTS: Data from 52 Roma and 98 Caucasian SLE patients were included. Roma SLE patients had a higher risk (odds ratio 2.56, 95% CI 1.02-6.39) and prevalence of APS (28.8% vs. 13.3%, P = 0.027). Furthermore, Roma SLE patients had a statistically significant higher prevalence of abortions (23.5% vs. 10.2%, P = 0.049). In relation to other APS diagnostic criteria, Roma SLE patients had a non-statistically significant higher prevalence of fetal deaths (14.3% vs. 5.1%, P = 0.106) and thrombotic events (21.1% vs. 12.2%, P = 0.160). In relation to SLE clinical features, Roma patients had a significantly higher prevalence of arthritis (75% vs. 57.1%, P = 0.034) and non-significant higher prevalence of serositis (44.2% vs. 29.6%, P = 0.104), discoid lesions (11.5% vs. 5.1%, P = 0.191), oral ulcers (46.1% vs. 34.7%, P = 0.218) and livedo reticularis (21.1% vs. 15.3%, P = 0.374). No statistically significant differences were found in the Systemic Lupus International Collaborating Clinics Damage Index or the autoimmune serological profile | ||
| 520 | |a CONCLUSION: Prevalence and risk of APS were significantly higher in Roma SLE patients. Furthermore, Roma patients had a significantly higher prevalence of abortions and a non-significant higher prevalence of fetal deaths and thrombotic events | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a clinical aspects | |
| 650 | 4 | |a disease etiology and pathogenesis - human | |
| 650 | 4 | |a drug treatment | |
| 650 | 4 | |a epidemiology | |
| 650 | 4 | |a systemic lupus erythematous | |
| 650 | 7 | |a Antibodies, Antiphospholipid |2 NLM | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 700 | 1 | |a Pardo-Cabello, Alfredo J |e verfasserin |4 aut | |
| 700 | 1 | |a Vargas-Hitos, José A |e verfasserin |4 aut | |
| 700 | 1 | |a Zamora-Pasadas, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Navarrete-Navarrete, Nuria |e verfasserin |4 aut | |
| 700 | 1 | |a Sabio, José M |e verfasserin |4 aut | |
| 700 | 1 | |a Jáimez-Gámiz, Laura |e verfasserin |4 aut | |
| 700 | 1 | |a Ríos-Fernandez, Raquel |e verfasserin |4 aut | |
| 700 | 1 | |a Ortego-Centeno, Norberto |e verfasserin |4 aut | |
| 700 | 1 | |a Ayala-Gutierrez, M Mar |e verfasserin |4 aut | |
| 700 | 1 | |a de Ramón, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Colodro-Ruíz, Agustín |e verfasserin |4 aut | |
| 700 | 1 | |a Micó-Giner, Luisa |e verfasserin |4 aut | |
| 700 | 1 | |a Castillo-Palma, María J |e verfasserin |4 aut | |
| 700 | 1 | |a Robles-Marhuenda, Ángel |e verfasserin |4 aut | |
| 700 | 1 | |a Luna-Del Castillo, Juan de Dios |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Alonso, Juan |e verfasserin |4 aut | |
| 700 | 0 | |a Spanish Autoimmune Diseases Study Group (GEAS) |e verfasserin |4 aut | |
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