Structures of the K35 and K15 capsular polysaccharides of Acinetobacter baumannii LUH5535 and LUH5554 containing amino and diamino uronic acids

Copyright © 2017 Elsevier Ltd. All rights reserved..

Capsular polysaccharides were isolated from A. baumannii LUH5535 (K35 CPS) and LUH5554 (K15 CPS) and studied by 1D and 2D 1H and 13C NMR spectroscopy. The CPSs were found to consist of linear tetrasaccharide repeats (K units) containing 2-acetamido-2-deoxy-d-galacturonic acid (K35) or 2,3-diacetamido-2,3-deoxy-d-glucuronic acid (K15) and 2,4-diacetamido-2,4,6-trideoxy-d-glucose (both CPSs). The K35 unit includes three O-acetyl groups on different GalNAcA residues. A. baumannii LUH5535 and LUH5554 carry the KL35 and KL15 gene clusters, respectively, and putatively assigned functions of genes in these clusters were consistent with the CPS structures established.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:448

Enthalten in:

Carbohydrate research - 448(2017) vom: 07. Aug., Seite 28-34

Sprache:

Englisch

Beteiligte Personen:

Shashkov, Alexander S [VerfasserIn]
Liu, Bin [VerfasserIn]
Kenyon, Johanna J [VerfasserIn]
Popova, Anastasiya V [VerfasserIn]
Shneider, Mikhail M [VerfasserIn]
Senchenkova, Sof'ya N [VerfasserIn]
Arbatsky, Nikolay P [VerfasserIn]
Miroshnikov, Konstantin A [VerfasserIn]
Wang, Lei [VerfasserIn]
Knirel, Yuriy A [VerfasserIn]

Links:

Volltext

Themen:

2,3-Diacetamido-2,3-deoxy-d-glucuronic acid
2,4-Diacetamido-2,4,6-trideoxy-d-glucose
2-Acetamido-2-deoxy-d-galacturonic acid
Acinetobacter baumannii
Capsular polysaccharide structure
Journal Article
K locus
Polysaccharides, Bacterial
Uronic Acids

Anmerkungen:

Date Completed 22.03.2018

Date Revised 22.03.2018

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.carres.2017.05.017

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM272585548