Validity Assessment of Low-risk SCORE Function and SCORE Function Calibrated to the Spanish Population in the FRESCO Cohorts
Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved..
INTRODUCTION AND OBJECTIVES: To assess the validity of the original low-risk SCORE function without and with high-density lipoprotein cholesterol and SCORE calibrated to the Spanish population.
METHODS: Pooled analysis with individual data from 12 Spanish population-based cohort studies. We included 30 919 individuals aged 40 to 64 years with no history of cardiovascular disease at baseline, who were followed up for 10 years for the causes of death included in the SCORE project. The validity of the risk functions was analyzed with the area under the ROC curve (discrimination) and the Hosmer-Lemeshow test (calibration), respectively.
RESULTS: Follow-up comprised 286 105 persons/y. Ten-year cardiovascular mortality was 0.6%. The ratio between estimated/observed cases ranged from 9.1, 6.5, and 9.1 in men and 3.3, 1.3, and 1.9 in women with original low-risk SCORE risk function without and with high-density lipoprotein cholesterol and calibrated SCORE, respectively; differences were statistically significant with the Hosmer-Lemeshow test between predicted and observed mortality with SCORE (P < .001 in both sexes and with all functions). The area under the ROC curve with the original SCORE was 0.68 in men and 0.69 in women.
CONCLUSIONS: All versions of the SCORE functions available in Spain significantly overestimate the cardiovascular mortality observed in the Spanish population. Despite the acceptable discrimination capacity, prediction of the number of fatal cardiovascular events (calibration) was significantly inaccurate.
| Errataetall: |
ErratumIn: Rev Esp Cardiol (Engl Ed). 2018 May 18;:. - PMID 29784548 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:71 |
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| Enthalten in: |
Revista espanola de cardiologia (English ed.) - 71(2018), 4 vom: 02. Apr., Seite 274-282 |
| Sprache: |
Englisch |
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| Links: |
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| Anmerkungen: |
Date Completed 24.09.2018 Date Revised 10.12.2019 published: Print-Electronic ErratumIn: Rev Esp Cardiol (Engl Ed). 2018 May 18;:. - PMID 29784548 Citation Status MEDLINE |
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| doi: |
10.1016/j.rec.2017.03.030 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272469394 |
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| 100 | 1 | |a Baena-Díez, José Miguel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Validity Assessment of Low-risk SCORE Function and SCORE Function Calibrated to the Spanish Population in the FRESCO Cohorts |
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| 500 | |a Date Completed 24.09.2018 | ||
| 500 | |a Date Revised 10.12.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ErratumIn: Rev Esp Cardiol (Engl Ed). 2018 May 18;:. - PMID 29784548 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a INTRODUCTION AND OBJECTIVES: To assess the validity of the original low-risk SCORE function without and with high-density lipoprotein cholesterol and SCORE calibrated to the Spanish population | ||
| 520 | |a METHODS: Pooled analysis with individual data from 12 Spanish population-based cohort studies. We included 30 919 individuals aged 40 to 64 years with no history of cardiovascular disease at baseline, who were followed up for 10 years for the causes of death included in the SCORE project. The validity of the risk functions was analyzed with the area under the ROC curve (discrimination) and the Hosmer-Lemeshow test (calibration), respectively | ||
| 520 | |a RESULTS: Follow-up comprised 286 105 persons/y. Ten-year cardiovascular mortality was 0.6%. The ratio between estimated/observed cases ranged from 9.1, 6.5, and 9.1 in men and 3.3, 1.3, and 1.9 in women with original low-risk SCORE risk function without and with high-density lipoprotein cholesterol and calibrated SCORE, respectively; differences were statistically significant with the Hosmer-Lemeshow test between predicted and observed mortality with SCORE (P < .001 in both sexes and with all functions). The area under the ROC curve with the original SCORE was 0.68 in men and 0.69 in women | ||
| 520 | |a CONCLUSIONS: All versions of the SCORE functions available in Spain significantly overestimate the cardiovascular mortality observed in the Spanish population. Despite the acceptable discrimination capacity, prediction of the number of fatal cardiovascular events (calibration) was significantly inaccurate | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Validation Study | |
| 650 | 4 | |a Cardiovascular disease | |
| 650 | 4 | |a Cardiovascular mortality | |
| 650 | 4 | |a Coronary disease | |
| 650 | 4 | |a Enfermedad coronaria | |
| 650 | 4 | |a Enfermedades cardiovasculares | |
| 650 | 4 | |a Funciones de riesgo | |
| 650 | 4 | |a Ictus | |
| 650 | 4 | |a Mortalidad cardiovascular | |
| 650 | 4 | |a Prevención | |
| 650 | 4 | |a Prevention | |
| 650 | 4 | |a Risk functions | |
| 650 | 4 | |a Stroke | |
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