A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells
Copyright © 2017 Elsevier B.V. All rights reserved..
Fetal exposure to synthetic glucocorticoids reprograms distinct neural circuits in the developing brain, often in a sex-specific manner, via mechanisms that remain poorly understood. To reveal whether such reprogramming is associated with select molecular signatures, we characterized the transcriptome of primary, embryonic mouse cerebral cortical and hypothalamic neural progenitor/stem cells derived from individual male and female embryos exposed to the synthetic glucocorticoid, dexamethasone. Gene expression profiling by RNA-Seq identified differential expression of common and unique genes based upon brain region, sex, and/or dexamethasone exposure. These gene expression datasets provide a unique resource that will inform future studies examining the molecular mechanisms responsible for region- and sex-specific reprogramming of the fetal brain brought about by in utero exposure to excess glucocorticoids.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:471 |
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| Enthalten in: |
Molecular and cellular endocrinology - 471(2018) vom: 15. Aug., Seite 42-50 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Frahm, Krystle A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.03.2019 Date Revised 08.10.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.mce.2017.05.026 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272357855 |
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| 100 | 1 | |a Frahm, Krystle A |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A comparison of the sexually dimorphic dexamethasone transcriptome in mouse cerebral cortical and hypothalamic embryonic neural stem cells |
| 264 | 1 | |c 2018 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 08.03.2019 | ||
| 500 | |a Date Revised 08.10.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier B.V. All rights reserved. | ||
| 520 | |a Fetal exposure to synthetic glucocorticoids reprograms distinct neural circuits in the developing brain, often in a sex-specific manner, via mechanisms that remain poorly understood. To reveal whether such reprogramming is associated with select molecular signatures, we characterized the transcriptome of primary, embryonic mouse cerebral cortical and hypothalamic neural progenitor/stem cells derived from individual male and female embryos exposed to the synthetic glucocorticoid, dexamethasone. Gene expression profiling by RNA-Seq identified differential expression of common and unique genes based upon brain region, sex, and/or dexamethasone exposure. These gene expression datasets provide a unique resource that will inform future studies examining the molecular mechanisms responsible for region- and sex-specific reprogramming of the fetal brain brought about by in utero exposure to excess glucocorticoids | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cortex | |
| 650 | 4 | |a Development | |
| 650 | 4 | |a Glucocorticoids | |
| 650 | 4 | |a Hypothalamus | |
| 650 | 4 | |a Neural stem cells | |
| 650 | 4 | |a Sex differences | |
| 650 | 7 | |a RNA, Messenger |2 NLM | |
| 650 | 7 | |a Dexamethasone |2 NLM | |
| 650 | 7 | |a 7S5I7G3JQL |2 NLM | |
| 700 | 1 | |a Waldman, Jacob K |e verfasserin |4 aut | |
| 700 | 1 | |a Luthra, Soumya |e verfasserin |4 aut | |
| 700 | 1 | |a Rudine, Anthony C |e verfasserin |4 aut | |
| 700 | 1 | |a Monaghan-Nichols, A Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Chandran, Uma R |e verfasserin |4 aut | |
| 700 | 1 | |a DeFranco, Donald B |e verfasserin |4 aut | |
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