Inhibition of the lateral habenular CaMKⅡ abolishes naloxone-precipitated conditioned place aversion in morphine-dependent mice
Copyright © 2017 Elsevier B.V. All rights reserved..
Addictive substances mediate positive and negative states promoting compulsive drug use. However, substrates for aversive effects of drugs are not fully understood. We found that inactivation of the lateral habenula (LHb) by microinjection of tetrodotoxin (TTX) abolished naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice. We also found that lateral habenular administration of KN-62, a specific inhibitor for calcium/calmodulin dependent protein kinase II (CaMKII), abolished naloxone-precipitated CPA in morphine-dependent mice. Furthermore, we found chronic morphine treatment induced overexpression of CaMKII in the LHb. In conclusion, our results suggest that the increased expression of CaMKII in the LHb is instrumental for morphine-driven aversive behaviors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:653 |
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| Enthalten in: |
Neuroscience letters - 653(2017) vom: 13. Juli, Seite 64-70 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Jing [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 30.04.2018 Date Revised 30.04.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neulet.2017.05.027 |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2017 Elsevier B.V. All rights reserved. | ||
| 520 | |a Addictive substances mediate positive and negative states promoting compulsive drug use. However, substrates for aversive effects of drugs are not fully understood. We found that inactivation of the lateral habenula (LHb) by microinjection of tetrodotoxin (TTX) abolished naloxone-precipitated conditioned place aversion (CPA) in morphine-dependent mice. We also found that lateral habenular administration of KN-62, a specific inhibitor for calcium/calmodulin dependent protein kinase II (CaMKII), abolished naloxone-precipitated CPA in morphine-dependent mice. Furthermore, we found chronic morphine treatment induced overexpression of CaMKII in the LHb. In conclusion, our results suggest that the increased expression of CaMKII in the LHb is instrumental for morphine-driven aversive behaviors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Calcium/calmodulin dependent protein kinase II (CaMKII) | |
| 650 | 4 | |a Conditioned place aversion (CPA) | |
| 650 | 4 | |a Lateral habenula (LHb) | |
| 650 | 4 | |a Morphine | |
| 650 | 7 | |a Narcotic Antagonists |2 NLM | |
| 650 | 7 | |a Narcotics |2 NLM | |
| 650 | 7 | |a Naloxone |2 NLM | |
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| 650 | 7 | |a 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine |2 NLM | |
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| 650 | 7 | |a Calcium-Calmodulin-Dependent Protein Kinase Type 2 |2 NLM | |
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| 700 | 1 | |a Li, Min |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Ping |e verfasserin |4 aut | |
| 700 | 1 | |a Zha, Yunhong |e verfasserin |4 aut | |
| 700 | 1 | |a He, Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Zicheng |e verfasserin |4 aut | |
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