Pharmacologic Properties of Novel Local Anesthetic Agents in Anesthesia Practice
Copyright © 2017 Elsevier Inc. All rights reserved..
Therapeutic duration of traditional local anesthetics when used in peripheral nerve blocks is normally limited. This article describes novel approaches to extend the duration of peripheral nerve blocks currently available or in development. Three newer approaches on extending the duration of peripheral nerve blocks include site-1 sodium channel blockers, novel local anesthetics delivery systems, and novel adjuvants of local anesthetics. Compared with plain amide-based and ester-based local anesthetics, alternative approaches show significant promise in decreasing postoperative pain, rescue opioid requirement, hospital length-of-stay, and overall health care cost, without compromising the established safety profile of traditional local anesthetics.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Anesthesiology clinics - 35(2017), 2 vom: 19. Juni, Seite 315-325 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
King, Chih H [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 06.11.2017 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.anclin.2017.01.019 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272084018 |
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| 520 | |a Therapeutic duration of traditional local anesthetics when used in peripheral nerve blocks is normally limited. This article describes novel approaches to extend the duration of peripheral nerve blocks currently available or in development. Three newer approaches on extending the duration of peripheral nerve blocks include site-1 sodium channel blockers, novel local anesthetics delivery systems, and novel adjuvants of local anesthetics. Compared with plain amide-based and ester-based local anesthetics, alternative approaches show significant promise in decreasing postoperative pain, rescue opioid requirement, hospital length-of-stay, and overall health care cost, without compromising the established safety profile of traditional local anesthetics | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Bupivacaine | |
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| 650 | 4 | |a Neosaxitoxin | |
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| 650 | 4 | |a Tetrodotoxin | |
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