Pharmacogenomics in Anesthesia

Copyright © 2017 Elsevier Inc. All rights reserved..

A significant number of commonly administered medications in anesthesia show wide clinical interpatient variability. Some of these include neuromuscular blockers, opioids, local anesthetics, and inhalation anesthetics. Individual genetic makeup may account for and predict cardiovascular outcomes after cardiac surgery. These interactions can manifest at any point in the perioperative period and may also only affect a specific system. A better understanding of pharmacogenomics will allow for more individually tailored anesthetics and may ultimately lead to better outcomes, decreased hospital stays, and improved patient satisfaction.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:35

Enthalten in:

Anesthesiology clinics - 35(2017), 2 vom: 19. Juni, Seite 285-294

Sprache:

Englisch

Beteiligte Personen:

Saba, Ramsey [VerfasserIn]
Kaye, Alan D [VerfasserIn]
Urman, Richard D [VerfasserIn]

Links:

Volltext

Themen:

Allele
Analgesics, Opioid
Anesthetics, Inhalation
Genetics
Genotype
Heterozygous
Homozygous
Journal Article
Neuromuscular Blocking Agents
Pharmacogenomics
Phenotype
Polymorphisms
Review
Single-nucleotide polymorphisms (SNP)

Anmerkungen:

Date Completed 06.11.2017

Date Revised 02.12.2018

published: Print

Citation Status MEDLINE

doi:

10.1016/j.anclin.2017.01.014

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM272083984