Immune plasma for the treatment of severe influenza : an open-label, multicentre, phase 2 randomised study

Copyright © 2017 Elsevier Ltd. All rights reserved..

BACKGROUND: Influenza causes substantial morbidity and mortality despite available treatments. Anecdotal reports suggest that plasma with high antibody titres to influenza might be of benefit in the treatment of severe influenza.

METHODS: In this randomised, open-label, multicentre, phase 2 trial, 29 academic medical centres in the USA assessed the safety and efficacy of anti-influenza plasma with haemagglutination inhibition antibody titres of 1:80 or more to the infecting strain. Hospitalised children and adults (including pregnant women) with severe influenza A or B (defined as the presence of hypoxia or tachypnoea) were randomly assigned to receive either two units (or paediatric equivalent) of anti-influenza plasma plus standard care, versus standard care alone, and were followed up for 28 days. The primary endpoint was time to normalisation of patients' respiratory status (respiratory rate of ≤20 breaths per min for adults or age-defined thresholds of 20-38 breaths per min for children) and a room air oxygen saturation of 93% or more. This study is registered with ClinicalTrials.gov, number NCT01052480.

FINDINGS: Between Jan 13, 2011, and March 2, 2015, 113 participants were screened for eligibility and 98 were randomly assigned from 20 out of 29 participating sites. Of the participants with confirmed influenza (by PCR), 28 (67%) of 42 in the plasma plus standard care group normalised their respiratory status by day 28 compared with 24 (53%) of 45 participants on standard care alone (p=0·069). The hazard ratio (HR) comparing plasma plus standard care with standard care alone was 1·71 (95% CI 0·96-3·06). Six participants died, one (2%) from the plasma plus standard care group and five (10%) from the standard care group (HR 0·19 [95% CI 0·02-1·65], p=0·093). Participants in the plasma plus standard care group had non-significant reductions in days in hospital (median 6 days [IQR 4-16] vs 11 days [5-25], p=0·13) and days on mechanical ventilation (median 0 days [IQR 0-6] vs 3 days [0-14], p=0·14). Fewer plasma plus standard care participants had serious adverse events compared with standard care alone recipients (nine [20%] of 46 vs 20 [38%] of 52, p=0·041), the most frequent of which were acute respiratory distress syndrome (one [2%] vs two [4%] patients) and stroke (one [2%] vs two [4%] patients).

INTERPRETATION: Although there was no significant effect of plasma treatment on the primary endpoint, the treatment seemed safe and well tolerated. A phase 3 randomised trial is now underway to further assess this intervention.

FUNDING: National Institute of Allergy and Infectious Diseases, US National Institutes of Health.

Errataetall:

CommentIn: Lancet Respir Med. 2017 Jun;5(6):462-464. - PMID 28522353

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:5

Enthalten in:

The Lancet. Respiratory medicine - 5(2017), 6 vom: 07. Juni, Seite 500-511

Sprache:

Englisch

Beteiligte Personen:

Beigel, John H [VerfasserIn]
Tebas, Pablo [VerfasserIn]
Elie-Turenne, Marie-Carmelle [VerfasserIn]
Bajwa, Ednan [VerfasserIn]
Bell, Todd E [VerfasserIn]
Cairns, Charles B [VerfasserIn]
Shoham, Shmuel [VerfasserIn]
Deville, Jaime G [VerfasserIn]
Feucht, Eric [VerfasserIn]
Feinberg, Judith [VerfasserIn]
Luke, Thomas [VerfasserIn]
Raviprakash, Kanakatte [VerfasserIn]
Danko, Janine [VerfasserIn]
O'Neil, Dorothy [VerfasserIn]
Metcalf, Julia A [VerfasserIn]
King, Karen [VerfasserIn]
Burgess, Timothy H [VerfasserIn]
Aga, Evgenia [VerfasserIn]
Lane, H Clifford [VerfasserIn]
Hughes, Michael D [VerfasserIn]
Davey, Richard T [VerfasserIn]
IRC002 Study Team [VerfasserIn]
Tebas, Pablo [Sonstige Person]
Quinn, Joseph [Sonstige Person]
Jiang, Yan [Sonstige Person]
Elie-Turenne, Marie-Carmelle [Sonstige Person]
Hoelle, Robyn [Sonstige Person]
Iovine, Nicole [Sonstige Person]
Wills, Robert Shawn [Sonstige Person]
Pata, Socorro [Sonstige Person]
Huggins, Monique [Sonstige Person]
Manukian, Belinda [Sonstige Person]
Bajwa, Ednan [Sonstige Person]
Holland, Carrie [Sonstige Person]
Brait, Kelsey [Sonstige Person]
Hunt, Taylor [Sonstige Person]
Stowell, Christopher [Sonstige Person]
Slater, Amy [Sonstige Person]
Bell, Todd E [Sonstige Person]
Townsends, Mary [Sonstige Person]
Cairns, Charles B [Sonstige Person]
Quackenbush, Eugenia B [Sonstige Person]
Park, Yara A [Sonstige Person]
Jordan, Paul Gaither [Sonstige Person]
Blanchet, Cherie [Sonstige Person]
Chronowski, Kevin [Sonstige Person]
Alvarez, Kathleen [Sonstige Person]
Shoham, Shmuel [Sonstige Person]
Ostrander, Darin [Sonstige Person]
Woessner, Terry [Sonstige Person]
Thoman, Sandra [Sonstige Person]
Deville, Jaime G [Sonstige Person]
Lin, James [Sonstige Person]
Ziman, Alyssa [Sonstige Person]
Shankar, Kavita [Sonstige Person]
Feucht, Eric [Sonstige Person]
Blok, Tom [Sonstige Person]
Batts, Don [Sonstige Person]
Beck, Bob [Sonstige Person]
Massey, Gail [Sonstige Person]
Bradley, Carol [Sonstige Person]
Feinberg, Judith [Sonstige Person]
Carey, Patricia [Sonstige Person]
Baer, Jenifer [Sonstige Person]
Whitehead, Eva Moore [Sonstige Person]
Kohrs, Sharon [Sonstige Person]
Giulitto, Robert [Sonstige Person]
Schofield, Christina [Sonstige Person]
Fairchok, Mary [Sonstige Person]
Chambers, Susan [Sonstige Person]
Baker, Cindy [Sonstige Person]
Rn [Sonstige Person]
Parker, Michelle [Sonstige Person]
Harshbarger, Marta [Sonstige Person]
Nguyen, M Hong [Sonstige Person]
Carey, Mary Ellen [Sonstige Person]
Paronish, Julie [Sonstige Person]
Cornell, Frank [Sonstige Person]
Cramer, Jim [Sonstige Person]
Pakstis, Diana Lynn [Sonstige Person]
Ison, Michael G [Sonstige Person]
Wunderink, Richard [Sonstige Person]
Glesby, Marshall [Sonstige Person]
Ham, Kirsis [Sonstige Person]
Hughes, Valery [Sonstige Person]
Cushing, Melissa [Sonstige Person]
Goss, Cheryl [Sonstige Person]
Grenade, Joanne [Sonstige Person]
Park, Pauline K [Sonstige Person]
Napolitano, Lena M [Sonstige Person]
Raghavendran, Krishnan [Sonstige Person]
Hyzy, Robert C [Sonstige Person]
Davenport, Robertson [Sonstige Person]
Brierley, Kristin [Sonstige Person]
Downs, Theresa [Sonstige Person]
Gong, Michelle Ng [Sonstige Person]
Uehlinger, Joan [Sonstige Person]
Lin, Michael [Sonstige Person]
Fritsche, Janice [Sonstige Person]
Green, Tondria [Sonstige Person]
McLeod, Bruce [Sonstige Person]
Patel, Deena [Sonstige Person]
Bavaro, Mary F [Sonstige Person]
Deiss, Robert [Sonstige Person]
Brandt, Carolyn [Sonstige Person]
Cammarata, Stephanie [Sonstige Person]
Kremp, Allan [Sonstige Person]
Hollis-Perry, Karine [Sonstige Person]
Lalani, Tahaniyat [Sonstige Person]
Banks, Susan [Sonstige Person]
Johnson, Jacqueline [Sonstige Person]
Maguire, Jason [Sonstige Person]
McNiff, Janet [Sonstige Person]
Rigg, Leslie E [Sonstige Person]
Ganesan, Anuradha [Sonstige Person]
Barahona, Irma [Sonstige Person]
Danko, Janine [Sonstige Person]
Spencer, Steven [Sonstige Person]
Stagliano, David [Sonstige Person]
Burgess, Timothy [Sonstige Person]
Talmor, Daniel [Sonstige Person]
Mohammed, Monique [Sonstige Person]

Links:

Volltext

Themen:

Clinical Trial, Phase II
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Anmerkungen:

Date Completed 11.04.2018

Date Revised 08.04.2022

published: Print-Electronic

ClinicalTrials.gov: NCT01052480

CommentIn: Lancet Respir Med. 2017 Jun;5(6):462-464. - PMID 28522353

Citation Status MEDLINE

doi:

10.1016/S2213-2600(17)30174-1

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM272050997