Uric acid and blood pressure : exploring the role of uric acid production in The Maastricht Study
OBJECTIVE: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension.
METHODS: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension.
RESULTS: After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations.
CONCLUSION: Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Journal of hypertension - 35(2017), 10 vom: 15. Okt., Seite 1968-1975 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Scheepers, Lieke E J M [VerfasserIn] |
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| Anmerkungen: |
Date Completed 26.03.2018 Date Revised 08.04.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1097/HJH.0000000000001417 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272034002 |
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| 100 | 1 | |a Scheepers, Lieke E J M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Uric acid and blood pressure |b exploring the role of uric acid production in The Maastricht Study |
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| 500 | |a Date Revised 08.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Accumulation of reactive oxygen species by increased uric acid production has been suggested as a possible underlying mechanism for the association between uric acid and high blood pressure (BP). We, therefore, investigated the association between serum uric acid concentration and 24-h urinary uric acid excretion, as proxy for uric acid production, with ambulatory 24-h blood pressure and hypertension | ||
| 520 | |a METHODS: Cross-sectional analyses were conducted among 2555 individuals [52% men, mean age 60.0 ± 8.2 years; 27% type 2 diabetes (by design)] from The Maastricht Study. Multivariable regression analyses were performed to investigate the association of serum uric acid and 24-h urinary uric acid excretion with 24-h pulse pressure, 24-h mean arterial pressure (MAP), and hypertension | ||
| 520 | |a RESULTS: After adjustment for traditional hypertension risk factors, serum uric acid concentration (per SD of 81 μmol/l) was associated with higher 24-h MAP [β 0.63 mmHg; confidence interval (CI) 0.27-1.00] and positively associated with hypertension (odds ratio 1.43; CI 1.27-1.61). Urinary uric acid excretion (per SD of 140 mg/day/1.73 m) was associated with higher 24-h MAP (β 0.79 mmHg; CI 0.46-1.12) and with hypertension (odds ratio 1.13; CI 1.02-1.25). There was no significant association between serum and 24-h urinary uric acid excretion with 24-h pulse pressure. There was no interaction with sex or age for the aforementioned associations | ||
| 520 | |a CONCLUSION: Higher serum and urinary uric acid concentrations were associated with higher 24-h MAP and hypertension. These results suggest that serum and 24-urinary uric acid concentrations, the latter as proxy for uric acid production are, independent of each other, associated with BP and hypertension | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Uric Acid |2 NLM | |
| 650 | 7 | |a 268B43MJ25 |2 NLM | |
| 700 | 1 | |a Boonen, Annelies |e verfasserin |4 aut | |
| 700 | 1 | |a Dagnelie, Pieter C |e verfasserin |4 aut | |
| 700 | 1 | |a Schram, Miranda T |e verfasserin |4 aut | |
| 700 | 1 | |a van der Kallen, Carla J H |e verfasserin |4 aut | |
| 700 | 1 | |a Henry, Ronald M A |e verfasserin |4 aut | |
| 700 | 1 | |a Kroon, Abraham A |e verfasserin |4 aut | |
| 700 | 1 | |a Stehouwer, Coen D A |e verfasserin |4 aut | |
| 700 | 1 | |a Arts, Ilja C W |e verfasserin |4 aut | |
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