A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases : A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine

Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:9

Enthalten in:

Nutrients - 9(2017), 5 vom: 15. Mai

Sprache:

Englisch

Beteiligte Personen:

Andersen, Vibeke [VerfasserIn]
Holmskov, Uffe [VerfasserIn]
Sørensen, Signe Bek [VerfasserIn]
Jawhara, Mohamad [VerfasserIn]
Andersen, Karina W [VerfasserIn]
Bygum, Anette [VerfasserIn]
Hvid, Lone [VerfasserIn]
Grauslund, Jakob [VerfasserIn]
Wied, Jimmi [VerfasserIn]
Glerup, Henning [VerfasserIn]
Fredberg, Ulrich [VerfasserIn]
Villadsen, Jan Alexander [VerfasserIn]
Kjær, Søren Geill [VerfasserIn]
Fallingborg, Jan [VerfasserIn]
Moghadd, Seyed A G R [VerfasserIn]
Knudsen, Torben [VerfasserIn]
Brodersen, Jacob [VerfasserIn]
Frøjk, Jesper [VerfasserIn]
Dahlerup, Jens F [VerfasserIn]
Nielsen, Ole Haagen [VerfasserIn]
Christensen, Robin [VerfasserIn]
Bojesen, Anders Bo [VerfasserIn]
Sorensen, Grith Lykke [VerfasserIn]
Thiel, Steffen [VerfasserIn]
Færgeman, Nils J [VerfasserIn]
Brandslund, Ivan [VerfasserIn]
Stensballe, Allan [VerfasserIn]
Schmidt, Erik Berg [VerfasserIn]
Franke, Andre [VerfasserIn]
Ellinghaus, David [VerfasserIn]
Rosenstiel, Philip [VerfasserIn]
Raes, Jeroen [VerfasserIn]
Heitmann, Berit [VerfasserIn]
Boye, Mette [VerfasserIn]
Nielsen, Charlotte Lindgaard [VerfasserIn]
Werner, Lars [VerfasserIn]
Kjeldsen, Jens [VerfasserIn]
Ellingsen, Torkell [VerfasserIn]

Links:

Volltext

Themen:

Biomarker
Biomarkers
Dietary Fats
Dietary Fiber
Dietary Proteins
Exercise
Fatty Acids, Unsaturated
Food
Journal Article
Micronutrients
Molecular epidemiology
Patient related outcome measures (PROMs)
Personalized medicine
Red meat
Smoking
Treatment outcome
Tumor Necrosis Factor-alpha
Western style diet (WSD)

Anmerkungen:

Date Completed 26.03.2018

Date Revised 02.12.2018

published: Electronic

Citation Status MEDLINE

doi:

10.3390/nu9050499

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM271899506