A palladium-catalyzed synthesis of (hetero)aryl-substituted imidazoles from aryl halides, imines and carbon monoxide
We describe here a tandem catalytic route to prepare imidazoles in a single operation from aryl iodides, imines and CO. The reaction involves a catalytic carbonylation of aryl halides with imines to form 1,3-dipoles, which undergo spontaneous 1,3-dipolar cycloaddition. Overall, this offers an alternative to coupling reactions to construct the (hetero)aryl-imidazole motif, where variation of the building blocks can allow the synthesis of broad families of imidazoles with independent control of all substituents.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2017 |
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Erschienen: |
2017 |
Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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Enthalten in: |
Chemical science - 8(2017), 2 vom: 01. Feb., Seite 1002-1007 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Tjutrins, Jevgenijs [VerfasserIn] |
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Anmerkungen: |
Date Revised 25.03.2024 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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doi: |
10.1039/c6sc04371b |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM271372176 |
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