Upregulation of MAOA in the hippocampus results in delayed depressive-like behaviors in burn mice
Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved..
OBJECTIVE: To observe depressive-like behavior and hippocampus monoamine oxidase A (MAOA) changes in burned mice.
METHODS: We tested depression and anxiety like behaviors of burn C57 mice with the sucrose preference test, forced swimming test (FST), open field test and elevated plus maze test and then detected the MAOA content and MAOA gene transcriptional levels in the hippocampus with western blot analysis and real-time quantitative PCR analysis. We then sought to reverse depressive-like behavior of burned mice with an MAOA inhibitor.
RESULTS: (1) Mice showed depressive and anxiety like behaviors one week after they were burned; (2) The content of MAOA in the hippocampus of burned mice was significantly higher than that in control mice (P<0.05); (3) MAOA gene transcription in the hippocampus of burned mice was significantly increased (MAOA mRNA was increased, P<0.05); (4) treatment with a MAOA inhibitor (phenelzine) significantly increased the sucrose preference rate and decreased FST immobility time in burned mice, and also decreased elevated expression of MAOA in the hippocampus of burned mice.
CONCLUSION: Burned mice showed "delayed" depressive-like behavior combined with a degree of anxiety; this phenomenon is likely associated with the increase in MAOA expression in the hippocampus.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 |
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| Enthalten in: |
Burns : journal of the International Society for Burn Injuries - 50(2024), 3 vom: 04. Apr., Seite 789-795 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Zhen [VerfasserIn] |
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| Links: |
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| Themen: |
57-50-1 |
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| Anmerkungen: |
Date Completed 08.04.2024 Date Revised 18.04.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.burns.2017.03.013 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM27100262X |
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| 245 | 1 | 0 | |a Upregulation of MAOA in the hippocampus results in delayed depressive-like behaviors in burn mice |
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| 500 | |a Date Revised 18.04.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 Elsevier Ltd and ISBI. All rights reserved. | ||
| 520 | |a OBJECTIVE: To observe depressive-like behavior and hippocampus monoamine oxidase A (MAOA) changes in burned mice | ||
| 520 | |a METHODS: We tested depression and anxiety like behaviors of burn C57 mice with the sucrose preference test, forced swimming test (FST), open field test and elevated plus maze test and then detected the MAOA content and MAOA gene transcriptional levels in the hippocampus with western blot analysis and real-time quantitative PCR analysis. We then sought to reverse depressive-like behavior of burned mice with an MAOA inhibitor | ||
| 520 | |a RESULTS: (1) Mice showed depressive and anxiety like behaviors one week after they were burned; (2) The content of MAOA in the hippocampus of burned mice was significantly higher than that in control mice (P<0.05); (3) MAOA gene transcription in the hippocampus of burned mice was significantly increased (MAOA mRNA was increased, P<0.05); (4) treatment with a MAOA inhibitor (phenelzine) significantly increased the sucrose preference rate and decreased FST immobility time in burned mice, and also decreased elevated expression of MAOA in the hippocampus of burned mice | ||
| 520 | |a CONCLUSION: Burned mice showed "delayed" depressive-like behavior combined with a degree of anxiety; this phenomenon is likely associated with the increase in MAOA expression in the hippocampus | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Burn | |
| 650 | 4 | |a Depressive-like behavior | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a Monoamine oxidase A | |
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| 700 | 1 | |a Rong, Xinzhou |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xuemin |e verfasserin |4 aut | |
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