Trimethyl chitosan-capped silver nanoparticles with positive surface charge : Their catalytic activity and antibacterial spectrum including multidrug-resistant strains of Acinetobacter baumannii

Copyright © 2017 Elsevier B.V. All rights reserved..

We report a facile route for the green synthesis of trimethyl chitosan nitrate-capped silver nanoparticles (TMCN-AgNPs) with positive surface charge. In this synthesis, silver nitrate, glucose, and trimethyl chitosan nitrate (TMCN) were used as silver precursor, reducing agent, and stabilizer, respectively. The reaction was carried out in a stirred basic aqueous medium at room temperature without the use of energy-consuming or expensive equipment. We investigated the effects of the concentrations of NaOH, glucose, and TMCN on the particle size, zeta potential, and formation yield. The AgNPs were characterized by UV-vis spectroscopy, photon correlation spectroscopy, laser Doppler anemometry, transmission electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The catalytic activity of the TMCN-AgNPs was studied by the reduction of 4-nitrophenol using NaBH4 as a reducing agent. We evaluated the antibacterial effects of the TMCN-AgNPs on Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus using the broth microdilution method. The results showed that both gram-positive and gram-negative bacteria were killed by the TMCN-AgNPs at very low concentration (<6.13μg/mL). Moreover, the TMCN-AgNPs also showed high antibacterial activity against clinically isolated multidrug-resistant A. baumannii strains, and the minimum inhibitory concentration (MIC) was ≤12.25μg/mL.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:155

Enthalten in:

Colloids and surfaces. B, Biointerfaces - 155(2017) vom: 01. Juli, Seite 61-70

Sprache:

Englisch

Beteiligte Personen:

Chang, T Y [VerfasserIn]
Chen, C C [VerfasserIn]
Cheng, K M [VerfasserIn]
Chin, C Y [VerfasserIn]
Chen, Y H [VerfasserIn]
Chen, X A [VerfasserIn]
Sun, J R [VerfasserIn]
Young, J J [VerfasserIn]
Chiueh, T S [VerfasserIn]

Links:

Volltext

Themen:

3M4G523W1G
4-nitrophenol
55X04QC32I
87L0B9CPPA
9012-76-4
Anti-Bacterial Agents
Antibacterial activity
Borohydrides
Catalytic activity
Chitosan
Glucose
Green synthesis
IY9XDZ35W2
Journal Article
Multidrug-resistant Acinetobacter baumannii
N-trimethyl chitosan chloride
Nitrophenols
Silver
Silver nanoparticles
Sodium Hydroxide
Sodium borohydride
Trimethyl chitosan nitrate
Y92ZL45L4R

Anmerkungen:

Date Completed 09.03.2018

Date Revised 09.03.2018

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.colsurfb.2017.03.054

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM270986502