Iron deficiency and red cell indices in patients with heart failure
© 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology..
AIMS: To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI.
METHODS AND RESULTS: We analysed clinical data of 1821 patients with HF [mean age 66 ± 13 years; 71% men; New York Heart Association class I/II/III/IV (11%/39%/44%/6%); left ventricular ejection fraction >45%: 19%]. Iron deficiency (ferritin <100 µg/L or ferritin 100-299 µg/L with transferrin saturation <20%) was common irrespective of the presence of anaemia (haemoglobin <12 g/dL in women and <13 g/dL in men) or low RCI, from 75% in anaemic subjects with low mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and MCH concentration (MCHC), to 36% in non-anaemic subjects with MCV, MCH, and MCHC above the lower limit of normal. After adjustment for clinical variables, iron parameters remained independently associated with haemoglobin, MCV, MCH, MCHC, mean reticulocyte haemoglobin content (CHR), and red cell distribution width (RDW). In multivariable Cox proportional hazard regression models there was a trend towards higher mortality in patients with vs. without ID when adjusted for relevant HF prognosticators and MCH or MCHC (but not haemoglobin, CHR or RDW).
CONCLUSIONS: Patients with HF should be routinely screened for ID irrespective of the presence of anaemia or abnormal RCI. The detrimental impact of ID on long-term survival in HF is partially independent of RCI.
| Errataetall: |
CommentIn: Eur J Heart Fail. 2018 Jan;20(1):123-124. - PMID 28990275 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:20 |
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| Enthalten in: |
European journal of heart failure - 20(2018), 1 vom: 10. Jan., Seite 114-122 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tkaczyszyn, Michał [VerfasserIn] |
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| Links: |
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| Themen: |
Anaemia |
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| Anmerkungen: |
Date Completed 16.10.2018 Date Revised 16.10.2018 published: Print-Electronic CommentIn: Eur J Heart Fail. 2018 Jan;20(1):123-124. - PMID 28990275 Citation Status MEDLINE |
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| doi: |
10.1002/ejhf.820 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM270746013 |
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| 100 | 1 | |a Tkaczyszyn, Michał |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Iron deficiency and red cell indices in patients with heart failure |
| 264 | 1 | |c 2018 | |
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| 500 | |a Date Completed 16.10.2018 | ||
| 500 | |a Date Revised 16.10.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Eur J Heart Fail. 2018 Jan;20(1):123-124. - PMID 28990275 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology. | ||
| 520 | |a AIMS: To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI | ||
| 520 | |a METHODS AND RESULTS: We analysed clinical data of 1821 patients with HF [mean age 66 ± 13 years; 71% men; New York Heart Association class I/II/III/IV (11%/39%/44%/6%); left ventricular ejection fraction >45%: 19%]. Iron deficiency (ferritin <100 µg/L or ferritin 100-299 µg/L with transferrin saturation <20%) was common irrespective of the presence of anaemia (haemoglobin <12 g/dL in women and <13 g/dL in men) or low RCI, from 75% in anaemic subjects with low mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and MCH concentration (MCHC), to 36% in non-anaemic subjects with MCV, MCH, and MCHC above the lower limit of normal. After adjustment for clinical variables, iron parameters remained independently associated with haemoglobin, MCV, MCH, MCHC, mean reticulocyte haemoglobin content (CHR), and red cell distribution width (RDW). In multivariable Cox proportional hazard regression models there was a trend towards higher mortality in patients with vs. without ID when adjusted for relevant HF prognosticators and MCH or MCHC (but not haemoglobin, CHR or RDW) | ||
| 520 | |a CONCLUSIONS: Patients with HF should be routinely screened for ID irrespective of the presence of anaemia or abnormal RCI. The detrimental impact of ID on long-term survival in HF is partially independent of RCI | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Anaemia | |
| 650 | 4 | |a Complete blood count | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Iron deficiency | |
| 650 | 4 | |a Red cell indices | |
| 650 | 7 | |a Hemoglobins |2 NLM | |
| 650 | 7 | |a Iron |2 NLM | |
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| 700 | 1 | |a Voors, Adriaan A |e verfasserin |4 aut | |
| 700 | 1 | |a van Veldhuisen, Dirk J |e verfasserin |4 aut | |
| 700 | 1 | |a Enjuanes, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Moliner-Borja, Pedro |e verfasserin |4 aut | |
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| 700 | 1 | |a Poloński, Lech |e verfasserin |4 aut | |
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| 700 | 1 | |a Ponikowski, Piotr |e verfasserin |4 aut | |
| 700 | 1 | |a van der Meer, Peter |e verfasserin |4 aut | |
| 700 | 1 | |a Jankowska, Ewa A |e verfasserin |4 aut | |
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